"Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, 41A, Aleea Gr. Ghica Voda, Iasi, Romania.
"Petru Poni" Institute of Macromolecular Chemistry of Romanian Academy, 41A, Aleea Gr. Ghica Voda, Iasi, Romania.
Carbohydr Polym. 2015 Mar 6;117:762-770. doi: 10.1016/j.carbpol.2014.10.050. Epub 2014 Oct 31.
The paper reports the preparation of twelve imino-chitosan biopolymer films by acid condensation of the amino groups of chitosan with various aldehydes, in aqueous medium, followed by slow water removal. FTIR spectroscopy has shown drastic conformation changes of chitosan macromolecular chains—from a stiff coil to a straight one, while wide angle X-ray diffraction evidenced a layered morphology of the biopolymer films. Contact angle and surface free energy determination indicated a higher biocompatibility of the new biopolymers as compared to the chitosan parent, while the microbiological screening demonstrated their self-defense properties against common and virulent pathogen agents. It was concluded that the reversibility of imine forming promotes the self-assembling of imino-chitosan biopolymer films into a lamellar morphology and, on the other hand, the slow release of the antimicrobial aldehyde in the microbiological culture. The obtained results demonstrate that chitosan polyamine is a challenging workbench to functional biodynamic materials.
本文报道了在水介质中，通过壳聚糖氨基与各种醛的酸缩合反应，制备十二种亚氨基壳聚糖生物聚合物薄膜，然后缓慢去除水分。傅里叶变换红外光谱（FTIR）显示壳聚糖大分子链发生了剧烈的构象变化——从僵硬的螺旋结构转变为直线型，而广角 X 射线衍射（WAXD）则证明了生物聚合物薄膜的层状形态。接触角和表面自由能的测定表明，与壳聚糖母体相比，这些新型生物聚合物具有更高的生物相容性，而微生物筛选则证明了它们对常见和有毒病原体的自卫特性。研究结论认为，亚胺形成的可逆性促进了亚氨基壳聚糖生物聚合物薄膜自组装成层状形态，另一方面，抗菌醛在微生物培养中的缓慢释放。研究结果表明，壳聚糖多胺是一种具有挑战性的功能性生物动态材料工作台。
