Craig Benjamin M, Reeve Bryce B, Brown Paul M, Cella David, Hays Ron D, Lipscomb Joseph, Simon Pickard A, Revicki Dennis A
Health Outcomes and Behavior, Moffitt Cancer Center and University of South Florida, Tampa, FL, USA.
Department of Health Policy and Management, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Value Health. 2014 Dec;17(8):846-53. doi: 10.1016/j.jval.2014.09.005.
Health valuation studies enhance economic evaluations of treatments by estimating the value of health-related quality of life (HRQOL). The Patient-Reported Outcomes Measurement Information System (PROMIS) includes a 29-item short-form HRQOL measure, the PROMIS-29.
To value PROMIS-29 responses on a quality-adjusted life-year scale, we conducted a national survey (N = 7557) using quota sampling based on the US 2010 Census. Based on 541 paired comparisons with over 350 responses each, pair-specific probabilities were incorporated into a weighted least-squared estimator.
All losses in HRQOL influenced choice; however, respondents valued losses in physical function, anxiety, depression, sleep, and pain more than those in fatigue and social functioning.
This article introduces a novel approach to valuing HRQOL for economic evaluations using paired comparisons and provides a tool to translate PROMIS-29 responses into quality-adjusted life-years.
健康评估研究通过估计与健康相关的生活质量（HRQOL）的价值来加强对治疗的经济评估。患者报告结果测量信息系统（PROMIS）包括一项由29个项目组成的简短HRQOL测量指标，即PROMIS-29。
为了在质量调整生命年量表上对PROMIS-29的回答进行估值，我们基于2010年美国人口普查采用配额抽样进行了一项全国性调查（N = 7557）。基于541对比较，每对比较有超过350个回答，将特定对的概率纳入加权最小二乘估计器。
HRQOL的所有损失都会影响选择；然而，与疲劳和社会功能方面的损失相比，受访者更看重身体功能、焦虑、抑郁、睡眠和疼痛方面的损失。
本文介绍了一种使用配对比较对HRQOL进行估值以用于经济评估的新方法，并提供了一种将PROMIS-29的回答转化为质量调整生命年的工具。
