Mochizuki Yumi, Harada Hiroyuki, Ikuta Minoru, Shimamoto Hiroaki, Tomioka Hirofumi, Tanaka Kae, Hirai Hideaki, Omura Ken
Department of Oral and Maxillofacial Surgery, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan.
Department of Oral and Maxillofacial Surgery, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan.
Oral Oncol. 2015 Feb;51(2):182-9. doi: 10.1016/j.oraloncology.2014.11.013. Epub 2014 Dec 10.
This study aimed to clarify the clinical characteristics of multiple primary carcinomas of the oral cavity.
We retrospectively reviewed the cases of 1015 patients who were treated during follow up for oral cancer at Tokyo Medical and Dental University between March 2001 and December 2012. We compared the clinical characteristics of 961 patients who developed single primary oral squamous cell carcinoma (SCC) during follow up and 54 patients who subsequently developed multiple primary carcinomas in the oral cavity.
Mean age at first diagnosis was significantly higher in patients with multiple primary carcinomas than single primary carcinoma. Multiple primary carcinomas showed a female predilection, were most prevalent in the gingiva, and tended to show earlier tumor and nodal stages than single primary carcinoma. The local recurrence rate was higher for multiple primary carcinomas than single primary carcinoma, and it increased with the number of multiple primary occurrences. The disease-specific survival rate at 10 years for patients with single primary carcinoma was 85.3% and that for patients with multiple primary carcinomas was 79.6%. The cumulative incidence rate for metachronous second multiple primary carcinomas after the onset of first carcinoma at 10 years was 8.0%. The recurrence of multiple primary carcinomas did not decrease the survival rate.
Differences were found in the clinical characteristics between patients with single oral SCC and those with multiple primary oral carcinomas. Early diagnosis and treatment as well as close long-term follow up are needed for patients with multiple primary oral carcinomas.
本研究旨在阐明口腔多原发性癌的临床特征。
我们回顾性分析了2001年3月至2012年12月期间在东京医科齿科大学接受口腔癌随访治疗的1015例患者的病例。我们比较了961例在随访期间发生单一原发性口腔鳞状细胞癌（SCC）的患者和54例随后发生口腔多原发性癌的患者的临床特征。
多原发性癌患者的首次诊断平均年龄显著高于单一原发性癌患者。多原发性癌表现出女性偏好，最常见于牙龈，并且与单一原发性癌相比，倾向于表现出更早的肿瘤和淋巴结分期。多原发性癌的局部复发率高于单一原发性癌，并且随着多原发性发生次数的增加而升高。单一原发性癌患者10年的疾病特异性生存率为85.3%，多原发性癌患者为79.6%。首次癌发病后10年异时性第二多原发性癌的累积发病率为8.0%。多原发性癌的复发并未降低生存率。
单一口腔SCC患者与口腔多原发性癌患者的临床特征存在差异。口腔多原发性癌患者需要早期诊断和治疗以及密切的长期随访。
