体内S1P1激活的成像。
Imaging S1P1 activation in vivo.
作者信息
Kono Mari, Proia Richard L
机构信息
Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Exp Cell Res. 2015 May 1;333(2):178-182. doi: 10.1016/j.yexcr.2014.11.023. Epub 2014 Dec 9.
Abstract
Sphingosine-1-phosphate receptor 1 (S1P1) is a G protein-coupled receptor that is activated by the sphingolipid ligand sphingosine-1-phosphate (S1P). S1P1 is widely expressed across tissues and, when activated, has broad functions in the immune, vascular and nervous systems. In several diseases in which inflammation plays a critical role, S1P1 activation has been found to be involved in pathogenesis. However, the details of S1P1 activation in vivo under different physiologic conditions are not well understood. Here we describe how a new in vivo methodology to identify S1P1 activation has helped increase understanding of the manner in which this signaling molecule functions both in homeostasis and during inflammation.
摘要
1-磷酸鞘氨醇受体1（S1P1）是一种G蛋白偶联受体，可被鞘脂配体1-磷酸鞘氨醇（S1P）激活。S1P1在各种组织中广泛表达，激活后在免疫、血管和神经系统中具有广泛功能。在几种炎症起关键作用的疾病中，已发现S1P1激活参与发病机制。然而，在不同生理条件下S1P1在体内激活的细节尚不清楚。在此，我们描述了一种用于识别S1P1激活的新体内方法如何有助于增进对这种信号分子在稳态和炎症过程中发挥作用方式的理解。
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