Olivera Ana, Allende Maria Laura, Proia Richard L
National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Biochim Biophys Acta. 2013 Jan;1831(1):193-202. doi: 10.1016/j.bbalip.2012.06.007. Epub 2012 Jun 23.
Sphingosine-1-phosphate (S1P) is a lipid that functions as a metabolic intermediate and a cellular signaling molecule. These roles are integrated when compartments with differing extracellular S1P concentrations are formed that serve to regulate functions within the immune and vascular systems, as well as during pathologic conditions. Gradients of S1P concentration are achieved by the organization of cells with specialized expression of S1P metabolic pathways within tissues. S1P concentration gradients underpin the ability of S1P signaling to regulate in vivo physiology. This review will discuss the mechanisms that are necessary for the formation and maintenance of S1P gradients, with the aim of understanding how a simple lipid controls complex physiology. This article is part of a Special Issue entitled Advances in Lysophospholipid Research.
鞘氨醇-1-磷酸（S1P）是一种脂质，作为代谢中间体和细胞信号分子发挥作用。当形成具有不同细胞外S1P浓度的区室时，这些作用得以整合，这些区室有助于调节免疫和血管系统内的功能，以及在病理状态下发挥作用。通过组织中具有S1P代谢途径特异性表达的细胞来实现S1P浓度梯度。S1P浓度梯度是S1P信号传导调节体内生理功能能力的基础。本综述将讨论形成和维持S1P梯度所必需的机制，旨在了解一种简单的脂质如何控制复杂的生理功能。本文是名为“溶血磷脂研究进展”的特刊的一部分。
