Zhou Pingting, Li Bo, Liu Furao, Zhang Meichao, Wang Qian, Liu Yuanhua, Yao Yuan, Li Dong
Department of Oncology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Department of Bone Tumor Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Mol Cancer. 2017 Feb 28;16(1):52. doi: 10.1186/s12943-017-0624-9.
The mechanical properties of epithelial to mesenchymal transition (EMT) and a pancreatic cancer subpopulation with stem cell properties have been increasingly recognized as potent modulators of the effective of therapy. In particular, pancreatic cancer stem cells (PCSCs) are functionally important during tumor relapse and therapy resistance. In this review we have surveyed recent advances in the role of EMT and PCSCs in tumor progression, metastasis and treatment resistance, and the mechanisms of integrated with biochemical signals and the underlying pathways involved in treatment resistance of pancreatic cancer. These findings highlight the importance of confirming stem-cells markers and complex molecular signaling pathways controlling EMT and cancer stem cells in pancreatic cancer during tumor formation, progression, and response to therapy.
上皮-间质转化（EMT）的力学特性以及具有干细胞特性的胰腺癌亚群已越来越被视为治疗效果的有力调节因子。特别是，胰腺癌干细胞（PCSCs）在肿瘤复发和治疗耐药过程中具有重要功能。在本综述中，我们探讨了EMT和PCSCs在肿瘤进展、转移和治疗耐药中的作用的最新进展，以及与生化信号整合的机制和胰腺癌治疗耐药所涉及的潜在途径。这些发现凸显了在肿瘤形成、进展和对治疗的反应过程中，确认胰腺癌中控制EMT和癌症干细胞的干细胞标志物和复杂分子信号通路的重要性。
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