Chen Jiu, Zhang Yan, Wei Dunhong, Wu Xingqu, Fu Qinghai, Xu Fan, Wang Huan, Ye Ming, Ma Wentao, Yang Laiqi, Zhang Zhijun
Center for Mental Disease Control and Prevention, Third Hospital of the People׳s Liberation Army, Baoji 721004, Shaanxi Province, PR China; Neurologic Department of Affiliated ZhongDa Hospital, Neuropsychiatric Institute and Medical School of Southeast University, Nanjing 210009, Jiangsu Province, PR China.
Center for Mental Disease Control and Prevention, Third Hospital of the People׳s Liberation Army, Baoji 721004, Shaanxi Province, PR China.
J Affect Disord. 2015 Mar 15;174:173-9. doi: 10.1016/j.jad.2014.11.049. Epub 2014 Dec 3.
Mismatch negativity (MMN) and P3a components are sequential and co-occur. MMN represents the pre-attentive index of deviance detection and P3a represents the attention orienting response. Major depressive disorder (MDD) is characterized by impaired pre-attentive information processing. To assess whether impaired pre-attentive information processing can lead to an impairment of subsequent orienting process as the neurophysiological transmission spreads from MMN to P3a in MDD.
MMN/P3a was obtained during a two-tone auditory paradigm with 8% duration deviants in 45 first-episode major depression subjects (F-MD), 40 recurrent major depression subjects (R-MD), and 46 healthy controls (HC).
Compared with HC, F-MD and R-MD had lower MMN amplitudes and no differences were found between F-MD and R-MD. Notably, R-MD had lower P3a amplitudes and longer P3a latencies compared to HC, while F-MD had no differences. Interestingly, no correlations were found between the severity of depression and the deficits of MMN amplitude. The deficits of P3a amplitude, however, were negatively correlated with the severity of depression in F-MD and R-MD. Furthermore, the P3a amplitude deficits were positively correlated with the number of episodes in R-MD.
Patients were on antidepressant medication.
The recurrence of depressive episodes can lead to impaired pre-attentive information processing, causing an impairment of subsequent orienting process as the neurophysiological transmission from MMN to P3a. It further suggests that the impaired processing indexed by MMN amplitude may be a stable trait biomarker for the appearance of depression, while P3a amplitude can be used a potential biomarker for recurrence.
失匹配负波（MMN）和P3a成分相继出现且同时存在。MMN代表偏差检测的前注意指标，P3a代表注意定向反应。重度抑郁症（MDD）的特征是前注意信息处理受损。目的是评估在前注意信息处理受损时，随着神经生理传导从MMN扩散到P3a，在MDD中后续定向过程是否也会受损。
在双音听觉范式中，对45名首发重度抑郁症患者（F-MD）、40名复发性重度抑郁症患者（R-MD）和46名健康对照者（HC）进行MMN/P3a检测，偏差音持续时间为8%。
与HC相比，F-MD和R-MD的MMN波幅较低，F-MD和R-MD之间未发现差异。值得注意的是，与HC相比，R-MD的P3a波幅较低且P3a潜伏期较长，而F-MD则无差异。有趣的是，未发现抑郁严重程度与MMN波幅缺陷之间存在相关性。然而，F-MD和R-MD中P3a波幅缺陷与抑郁严重程度呈负相关。此外，R-MD中P3a波幅缺陷与发作次数呈正相关。
患者正在服用抗抑郁药物。
抑郁发作的复发会导致前注意信息处理受损，随着神经生理从MMN传导到P3a，会导致后续定向过程受损。这进一步表明，以MMN波幅为指标的处理受损可能是抑郁症出现的稳定特质生物标志物，而P3a波幅可作为复发的潜在生物标志物。
