University of Cincinnati College of Medicine, Department of Environmental Health, PO Box 670056, Cincinnati, OH 45267-0056, USA.
Environ Pollut. 2014 Jan;184:327-34. doi: 10.1016/j.envpol.2013.09.008. Epub 2013 Oct 1.
PFC serum concentrations were measured in 6-8 year-old girls in Greater Cincinnati (GC) (N = 353) and the San Francisco Bay Area (SFBA) (N = 351). PFOA median concentration was lower in the SFBA than GC (5.8 vs. 7.3 ng/mL). In GC, 48/51 girls living in one area had PFOA concentrations above the NHANES 95th percentile for children 12-19 years (8.4 ng/mL), median 22.0 ng/mL. The duration of being breast fed was associated with higher serum PFOA at both sites and with higher PFOS, PFHxS and Me-PFOSA-AcOH concentrations in GC. Correlations of the PFC analytes with each other suggest that a source upriver from GC may have contributed to exposures through drinking water, and water treatment with granular activated carbon filtration resulted in less exposure for SWO girls compared to those in NKY. PFOA has been characterized as a drinking water contaminant, and water treatment systems effective in removing PFCs will reduce body burdens.
在辛辛那提大地区（GC）（N=353）和旧金山湾区（SFBA）（N=351），对 6-8 岁女童的血清 PFC 浓度进行了测量。SFBA 地区的 PFOA 中位数浓度低于 GC（5.8 与 7.3ng/ml）。在 GC，居住在一个地区的 51 名女童中有 48 名的 PFOA 浓度高于 NHANES 儿童 12-19 岁的第 95 百分位数（8.4ng/ml），中位数为 22.0ng/ml。在两个地区，母乳喂养时间与血清中更高的 PFOA 浓度有关，与 GC 中更高的 PFOS、PFHxS 和 Me-PFOSA-AcOH 浓度有关。PFC 分析物之间的相关性表明，GC 上游的一个来源可能通过饮用水和使用颗粒活性炭过滤的水进行处理，导致 SWO 女童的暴露水平低于 NKY 女童。PFOA 已被确定为饮用水污染物，有效去除 PFCs 的水系统将降低体内负荷。
