Cottone S, Guarino L, Arsena R, Scazzone C, Tornese F, Guarneri M, Guglielmo C, Bono A, Mulè G
Nephrology and Hypertension Unit, Dipartimento Biomedico di Medicina Interna e Specialistica, Università di Palermo, Palermo, Italy.
Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Università di Palermo, Palermo, Italy.
J Hum Hypertens. 2015 Aug;29(8):483-7. doi: 10.1038/jhh.2014.113. Epub 2014 Dec 11.
Several studies analyzed 25-hydroxyvitamin D (25[OH]D) and blood pressure (BP) relationship with mixed results. Moreover, a relationship between the risk of hypertension and vitamin D receptor (VDR) gene polymorphisms, FokI and BsmI, was reported. This study was aimed to analyze these relationships in essential hypertensive (EH) patients. Seventy-one EH patients, 18-75 years old, were enrolled. Patients underwent clinical BP, 24-h ambulatory BP monitoring, 25[OH]D and plasma renin activity (PRA) evaluations. FokI and BsmI VDR polymorphisms were analyzed and compared with those of 72 healthy controls. In EH patients, the median 25[OH]D levels were lower than 30 ng ml(-1). We found a significant negative correlation between 25[OH]D and 24-h systolic BP (r = -0.277, P = 0.043). This correlation persisted in backward stepwise multivariate analyses (β = -0.337; P = 0.022), after adjustment for age, gender, body mass index, glomerular filtration rate, and PRA. We did not observe statistically significant correlation between 25[OH]D and PRA. We compared the allelic frequencies and genotype distribution between patients and controls, and FokI and BsmI VDR polymorphisms were not associated either with hypertensive status or with PRA. Further wide studies are needed to clarify this relationship.
多项研究分析了25-羟维生素D（25[OH]D）与血压（BP）之间的关系，结果不一。此外，有报道称高血压风险与维生素D受体（VDR）基因多态性FokI和BsmI之间存在关联。本研究旨在分析原发性高血压（EH）患者中的这些关系。纳入了71例年龄在18至75岁之间的EH患者。患者接受了临床血压、24小时动态血压监测、25[OH]D和血浆肾素活性（PRA）评估。分析了FokI和BsmI VDR基因多态性，并与72名健康对照者的进行比较。在EH患者中，25[OH]D水平中位数低于30 ng/ml。我们发现25[OH]D与24小时收缩压之间存在显著负相关（r = -0.277，P = 0.043）。在对年龄、性别、体重指数、肾小球滤过率和PRA进行调整后，这种相关性在向后逐步多变量分析中仍然存在（β = -0.337；P = 0.022）。我们未观察到25[OH]D与PRA之间存在统计学显著相关性。我们比较了患者与对照者之间的等位基因频率和基因型分布，FokI和BsmI VDR基因多态性与高血压状态或PRA均无关联。需要进一步开展广泛研究以阐明这种关系。
