Dakota Iwan, Adda'i Muhamad Fajri, Maulana Rido, Ivan Ignatius, Sukmawan Renan, Widyantoro Bambang
Department of Cardiology and Vascular Medicine, Faculty of Medicine, National Cardiovascular Centre Harapan Kita, Universitas Indonesia, Jakarta, Indonesia.
School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia.
PLoS One. 2024 Dec 23;19(12):e0314886. doi: 10.1371/journal.pone.0314886. eCollection 2024.
The association between Vitamin D Receptor (VDR) gene polymorphisms and essential hypertension (EH) remains controversial. We searched databases (Cochrane Library, EBSCO, EMBASE, LILACS, ProQuest, PubMed, Science Direct, Springer) for studies on VDR gene polymorphisms and EH until May 30, 2024, following PRISMA guidelines. RevMan 5.4.1 provided pooled odds ratio (OR) under Hardy-Weinberg Equilibrium based on allele, additive, dominant, and recessive genetic models. Meta-regression was performed using Comprehensive Meta Analysis V3. Twenty-two studies from thirteen countries were analyzed. The recessive model suggested lower EH risk in individuals with the recessive allele (bb) of BsmI (OR: 0.81; 95%CI, 0.69 to 0.94, p = 0.007; I2 = 35%, p = 0.13). No significant associations were found for FokI, ApaI, and TaqI polymorphisms. Methodological quality significantly influenced EH risk associated with the FokI polymorphism across allele, additive, and dominant models (All p<0.0005). Male proportion influenced EH risk in the additive model for the FokI polymorphism (p = 0.0235), while age impacted risk in the recessive model (p = 0.0327). FokI polymorphism's influence on EH risk varies by sex, age, and study quality. BsmI polymorphism is independently associated with lower EH risk in recessive homozygotes, with no significant associations found for ApaI and TaqI polymorphisms.
维生素D受体（VDR）基因多态性与原发性高血压（EH）之间的关联仍存在争议。我们按照PRISMA指南，检索了数据库（Cochrane图书馆、EBSCO、EMBASE、LILACS、ProQuest、PubMed、Science Direct、Springer），以查找截至2024年5月30日有关VDR基因多态性与EH的研究。RevMan 5.4.1基于等位基因、加性、显性和隐性遗传模型，在哈迪-温伯格平衡下提供合并优势比（OR）。使用Comprehensive Meta Analysis V3进行Meta回归分析。分析了来自13个国家的22项研究。隐性模型表明，携带BsmI隐性等位基因（bb）的个体患EH的风险较低（OR：0.81；95%CI，0.69至0.94，p = 0.007；I2 = 35%，p = 0.13）。未发现FokI、ApaI和TaqI基因多态性与EH有显著关联。方法学质量在等位基因、加性和显性模型中显著影响与FokI基因多态性相关的EH风险（所有p<0.0005）。男性比例在FokI基因多态性的加性模型中影响EH风险（p = 0.0235），而年龄在隐性模型中影响风险（p = 0.0327）。FokI基因多态性对EH风险的影响因性别、年龄和研究质量而异。BsmI基因多态性在隐性纯合子中与较低的EH风险独立相关，未发现ApaI和TaqI基因多态性与EH有显著关联。
