Xu S H
Zhonghua Bing Li Xue Za Zhi. 1989 Mar;18(1):47-9.
A model of transplantable human mucoid adenocarcinoma of rectum in BALB/C nu/nu nude mice (TNB 92), was established and 18 sub-transplantations were performed. The success rate of transplantation was 98% and the average tumor bearing life time of mice was 112 days. Histology and ultrastructures showed that the transplantable tumor retained the original structures of the human tumor. Chromosomal analysis of the tumor cells exhibited the same features of the human carcinoma and it also retained the function of secreting CEA. Frozen tissue of the tumor in liquid nitrogen after rehabilitation could be successfully retransplanted into nude mice again. It seems to be a useful model for further study of human rectal adenocarcinoma.
在BALB/C nu/nu裸鼠中建立了可移植性人直肠黏液腺癌模型（TNB 92），并进行了18次传代移植。移植成功率为98%，小鼠平均荷瘤生存期为112天。组织学和超微结构显示，可移植肿瘤保留了人肿瘤的原始结构。肿瘤细胞的染色体分析显示出与人癌相同的特征，并且还保留了分泌癌胚抗原的功能。肿瘤经液氮冷冻保存后，其冻存组织可再次成功移植到裸鼠体内。这似乎是进一步研究人直肠腺癌的一个有用模型。
