Kumar S, West D C, Ponting J M, Gattamaneni H R
Christie Hospital, Manchester, UK.
Int J Cancer. 1989 Sep 15;44(3):445-8. doi: 10.1002/ijc.2910440311.
The molecular mass of hyaluronic acid (HA) rather than its serum concentration alone may be a hallmark of certain types of malignancy. A radiometric assay was used to measure HA levels in 35 children with renal tumours [33 Wilms' tumours and 2 bone metastasizing renal tumours of childhood (BMRTC)] and 20 normal siblings of children with cancer. The HA level in the sera of normal children was barely detectable and had a molecular mass of 1-5 x 10(5). In both Wilms' and BMRTC patients, very high levels of HA were found in preoperative serum samples; these fell dramatically following surgical excision of the tumours. A novel finding of our study was the presence of low-molecular-mass HA (similar to the angiogenic fragments of HA) in the sera of BMRTC patients. In contrast, high-molecular-mass HA (which is not angiogenic) was found in the sera of Wilms' patients (2 x 10(6) kDa). Following surgery in BMRTC patients, not only did serum HA levels fall to a value within normal ranges, but also the HA which remained was of high molecular mass.
透明质酸（HA）的分子量而非仅其血清浓度可能是某些类型恶性肿瘤的一个标志。采用放射性测定法测量了35例肾肿瘤患儿（33例威尔姆斯瘤和2例儿童骨转移性肾肿瘤（BMRTC））以及20例癌症患儿的正常同胞的HA水平。正常儿童血清中的HA水平几乎检测不到，分子量为1 - 5×10⁵ 。在威尔姆斯瘤和BMRTC患者的术前血清样本中均发现HA水平非常高；肿瘤手术切除后这些水平急剧下降。我们研究的一个新发现是BMRTC患者血清中存在低分子量HA（类似于HA的血管生成片段）。相比之下，威尔姆斯瘤患者血清中发现的是高分子量HA（无血管生成性，2×10⁶ kDa）。BMRTC患者手术后，不仅血清HA水平降至正常范围内的值，而且剩余的HA为高分子量。
