Orozco Ana C, Muñoz Angélica M, Velásquez Claudia M, Uscátegui Rosa M, Parra María V, Patiño Fredy A, Manjarrés Luz M, Parra Beatriz E, Estrada Alejandro, Agudelo Gloria M
Grupo de Investigación en Alimentación y Nutrición Humana, Universidad de Antioquia, Medellín, Colombia.
Grupo de Investigación GENMOL, Universidad de Antioquia, Medellín, Colombia.
Biomedica. 2014 Oct-Dec;34(4):546-55. doi: 10.1590/S0120-41572014000400007.
Introduction : Obesity results from interaction between genetic and environmental risk factors.
To evaluate the effect of three gene variants and environmental factors on obesity and overweight in young people aged 10 to 18 years in a Colombian population.
A total of 424 subjects were selected and separated into three groups for a cross-sectional study; 100 obese and 112 overweight subjects were matched with 212 normal-weight controls. Associations were evaluated between excess weight and three genetic polymorphisms ( UCP3- rs1800849, FTO -rs17817449, and CAPN10 -rs3842570), as well as the family history, the time spent watching television and playing video games, and the diet.
A family history of obesity, the time spent watching television and playing video games, the lack of breastfeeding, a low consumption of cereals, legumes, fruits, vegetables, and a high consumption of fast foods were characteristics typically found in obese individuals compared to controls. A significant association between genotype I/I (SNP19 of CAPN10 ) and excess weight was found even with an active lifestyle. In addition, significant associations between the C/C genotype of the UCP3 gene and the G/G and T/T genotypes of the FTO gene and excess weight were found only in young sedentary individuals.
In this population, inadequate diet and sedentary lifestyle increased the risk of excess weight. Genotype I/I of SNP19 in CAPN10 was significantly associated with excess weight. In contrast, FTO and UCP3 variants exhibited effects only in sedentary environments.
引言：肥胖是由遗传和环境风险因素相互作用导致的。
评估三种基因变异和环境因素对哥伦比亚10至18岁青少年肥胖和超重的影响。
选取424名受试者，分为三组进行横断面研究；100名肥胖者和112名超重者与212名体重正常的对照组进行匹配。评估超重与三种基因多态性（UCP3 - rs1800849、FTO - rs17817449和CAPN10 - rs3842570）之间的关联，以及家族史、看电视和玩电子游戏的时间和饮食情况。
与对照组相比，肥胖者的典型特征包括肥胖家族史、看电视和玩电子游戏的时间、未进行母乳喂养、谷物、豆类、水果、蔬菜摄入量低以及快餐摄入量高。即使生活方式积极，也发现基因型I/I（CAPN10的SNP19）与超重之间存在显著关联。此外，仅在久坐不动的青少年中发现UCP3基因的C/C基因型和FTO基因的G/G及T/T基因型与超重之间存在显著关联。
在该人群中，饮食不均衡和久坐的生活方式增加了超重风险。CAPN10中SNP19的基因型I/I与超重显著相关。相比之下，FTO和UCP3变异仅在久坐环境中表现出影响。
