Oren R, Shouval D, Tur-Kaspa R
Department of Medicine A, Hadassah University Hospital, Jerusalem, Israel.
J Med Virol. 1989 Aug;28(4):261-3. doi: 10.1002/jmv.1890280411.
Hepatitis A virus (HAV) RNA was extracted from the sera of patients with acute hepatitis and then detected by molecular hybridization using cloned HAV complementary DNA (cDNA). HAV RNA was detected in 20 of 85 patients with acute HAV infection, mainly during the prodromal stage, or early during the icteric phase of the disease; it was detected as long as 21 days after its initial detection. Patients with HAV RNA in the serum had a significantly higher titer of anti-HAV IgM.
从急性肝炎患者的血清中提取甲型肝炎病毒（HAV）RNA，然后使用克隆的HAV互补DNA（cDNA）通过分子杂交进行检测。在85例急性HAV感染患者中，有20例检测到HAV RNA，主要在疾病的前驱期或黄疸期早期；在首次检测到HAV RNA后的长达21天内均可检测到。血清中存在HAV RNA的患者抗HAV IgM滴度明显更高。
