没食子酸癸酯对几种致病真菌的抗真菌活性
Antifungal Activity of Decyl Gallate against Several Species of Pathogenic Fungi.
作者信息
de Paula E Silva Ana Carolina Alves, Costa-Orlandi Caroline Barcelos, Gullo Fernanda Patrícia, Sangalli-Leite Fernanda, de Oliveira Haroldo Cesar, da Silva Julhiany de Fátima, Scorzoni Liliana, Pitangui Nayla de Souza, Rossi Suélen Andrea, Benaducci Tatiane, Wolf Vanessa Gonçalves, Regasini Luis Octávio, Petrônio Maicon Segalla, Silva Dulce Helena Siqueira, Bolzani Vanderlan S, Fusco-Almeida Ana Marisa, Mendes-Giannini Maria José Soares
机构信息
Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista Júlio Mesquita Filho (UNESP), Rodovia Araraquara-Jaú, km 1, 14 800 901 Araraquara, SP, Brazil.
Departamento de Química Orgânica, Instituto de Química, Universidade Estadual Paulista Júlio Mesquita Filho (UNESP), Rua Professor Francisco Degni, 55, Bairro Quitandinha, 14800-060 Araraquara, SP, Brazil.
出版信息
Evid Based Complement Alternat Med. 2014;2014:506273. doi: 10.1155/2014/506273. Epub 2014 Nov 20.
This work aims to demonstrate that the gallic acid structure modification to the decyl gallate (G14) compound contributed to increase the antifungal activity against several species of pathogenic fungi, mainly, Candida spp., Cryptococcus spp., Paracoccidioides spp., and Histoplasma capsulatum, according to standardized microdilution method described by Clinical Laboratory Standard Institute (CLSI) documents. Moreover this compound has a particularly good selectivity index value, which makes it an excellent candidate for broad-spectrum antifungal prototype and encourages the continuation of subsequent studies for the discovery of its mechanism of action.
这项工作旨在证明，将没食子酸结构修饰为没食子酸癸酯（G14）化合物有助于提高对几种致病真菌的抗真菌活性，主要是念珠菌属、隐球菌属、副球孢子菌属和荚膜组织胞浆菌，这是根据临床实验室标准协会（CLSI）文件中描述的标准化微量稀释法得出的结论。此外，该化合物具有特别良好的选择性指数值，这使其成为广谱抗真菌原型的优秀候选物，并鼓励继续进行后续研究以发现其作用机制。
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