Center for Cell and Gene Therapy, Baylor College of Medicine, Houston Methodist Hospital and Texas Children's Hospital , Houston TX, USA.
Clin Transl Immunology. 2014 Feb 28;3(2):e11. doi: 10.1038/cti.2014.2. eCollection 2014 Feb.
Viral infections remain a significant cause of morbidity and mortality after hematopoietic stem cell transplantation. Pharmacologic agents are effective against some pathogens, but they are costly and can be associated with significant toxicities. Thus, many groups have investigated adoptive T-cell transfer as a means of hastening immune reconstitution and preventing and treating viral infections. This review discusses the immunotherapeutic strategies that have been explored.
病毒感染仍然是造血干细胞移植后发病率和死亡率的重要原因。药物治疗对一些病原体有效，但成本高，且可能伴有严重的毒性。因此，许多研究小组已经研究了过继性 T 细胞转移作为加速免疫重建以及预防和治疗病毒感染的手段。本文讨论了已经探索过的免疫治疗策略。
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