Lopes Heno F, Klein Richard L, Garvey W Timothy, Goodfriend Theodore, Egan Brent M
Unidade de Hipertensao-Heart Institute (InCor), University of Sao Paulo Medical School, Av Dr Enéas C. de Aguiar, 44, Zip code 05403-904 São Paulo, Brazil ; Universidade Nove de Julho - UNINOVE, University of São Paulo Medical School, Av Dr Enéas C. de Aguiar, 44, Zip code 05403-904 São Paulo, Brazil.
Department of Pharmacology, Medical University of South Carolina, Charleston, South Carolina USA.
Diabetol Metab Syndr. 2014 Dec 2;6(1):132. doi: 10.1186/1758-5996-6-132. eCollection 2014.
Adipocyte-derived factors and regulators likely contribute to the metabolic syndrome (MetS) in patients with central obesity. This study was undertaken to assess the contribution of leptin, adiponectin, and acylation stimulating protein (ASP-C3ades/ARG) to hemodynamic (blood pressure [BP]) and metabolic (insulin, glucose, lipids) features of MetS.
In this study, leptin, adiponectin, and C3ades/ARG were measured at baseline and in response to an infusion of Intralipid(®) and heparin in 12 lean healthy controls and 12 patients with MetS.
Baseline plasma leptin (27.6 ± 6.2 vs. 10.9 ± 3.8 ng/mL, p < 0.01) and plasma C3ades/ARG (273 ± 79 vs 198 ± 57 mg/dL, p < 0.05) were higher in the MetS than control group, whereas baseline plasma adiponectin was higher in the control than MetS group (9.9 ± 1.9 vs. 5.4 ± 0.6 g/mL). Plasma leptin correlated with body mass index (BMI), systolic and diastolic BP (r = 0.53-0.77, p < 0.01). Conversely, adiponectin correlated inversely with insulin, glucose, waist circumference, and insulin sensitivity (r = 0.48-0.51, p ≤ 0.02). Plasma triglycerides increased similarly in MetS and control groups after 4-hours of Intralipid and heparin. C3ades/ARG increased only in lean volunteers. The decrease in triglycerides 1-hour post-infusion was lower in the MetS than control group (-116 ± 33 vs. -282 ± 81 mg/dL, p = 0.01) and correlated inversely with the change in C3ades/ARG.
These data suggest that leptin is more closely associated with hemodynamic (BP) aspects of MetS, whereas adiponectin and C3ades/ARG are more closely associated with metabolic components.
脂肪细胞衍生因子和调节剂可能在中心性肥胖患者的代谢综合征（MetS）中起作用。本研究旨在评估瘦素、脂联素和酰化刺激蛋白（ASP-C3ades/ARG）对MetS患者血流动力学（血压[BP]）和代谢（胰岛素、葡萄糖、脂质）特征的影响。
在本研究中，对12名健康瘦人对照组和12名MetS患者在基线时以及输注英脱利匹特（Intralipid®）和肝素后测定瘦素、脂联素和C3ades/ARG。
MetS组的基线血浆瘦素（27.6±6.2 vs. 10.9±3.8 ng/mL，p<0.01）和血浆C3ades/ARG（273±79 vs 198±57 mg/dL，p<0.05）高于对照组，而对照组的基线血浆脂联素高于MetS组（9.9±1.9 vs. 5.4±0.6 g/mL）。血浆瘦素与体重指数（BMI）、收缩压和舒张压相关（r=0.53-0.77，p<0.01）。相反，脂联素与胰岛素、葡萄糖、腰围和胰岛素敏感性呈负相关（r=0.48-0.51，p≤0.02）。在输注英脱利匹特和肝素4小时后，MetS组和对照组的血浆甘油三酯均有相似程度的升高。C3ades/ARG仅在瘦志愿者中升高。输注后1小时，MetS组甘油三酯的下降幅度低于对照组（-116±33 vs. -282±81 mg/dL，p=0.01），且与C3ades/ARG的变化呈负相关。
这些数据表明，瘦素与MetS的血流动力学（BP）方面关系更为密切，而脂联素和C3ades/ARG与代谢成分关系更为密切。
