Lopes Heno F, Martin Kelley L, Nashar Khaled, Morrow Jason D, Goodfriend Theodore L, Egan Brent M
Department of Pharmacology, Medical University of South Carolina, 96 Jonathan Lucas St, CSB 826H, Charleston, SC 29425, USA.
Hypertension. 2003 Mar;41(3):422-30. doi: 10.1161/01.HYP.0000053450.19998.11. Epub 2003 Feb 3.
Evidence suggests that obesity may raise blood pressure (BP) through oxidative stress-sensitive mechanisms and that the Dietary Approaches to Stop Hypertension combination diet (DASH-CD) may decrease BP by enhancing antioxidant capacity. To address this question, 12 obese patients with high-normal-to-stage 1 hypertension (hypertensives) and 12 lean normotensives were studied on their usual diets and after following the DASH-CD and a low-antioxidant diet in random sequence for 4 weeks each. Acute oxidative stress was induced by a 4-hour infusion of intralipid and heparin. Ferric-reducing activity of plasma (FRAP) and plasma F2-isoprostanes were measured as biomarkers of antioxidant capacity and oxidative stress, respectively. BP was lower in obese hypertensives on the DASH-CD than on the usual and low-antioxidant diets (-8.1+/-1.5/-7.4+/-1.6 mm Hg, P<0.05). BP did not change significantly in lean normotensives after 4 weeks on the DASH-CD but tended to rise on the low-antioxidant diet. FRAP on usual diets was higher in lean subjects than in obese subjects. FRAP increased in obese but not lean volunteers on the DASH-CD compared with usual diet, and the group difference disappeared. F2-isoprostanes increased from baseline during intralipid and heparin in both groups on the low-antioxidant diet but not in obese hypertensives on the DASH-CD. Among free-living obese hypertensives, the DASH-CD raises antioxidant capacity, lowers BP, and reduces oxidative stress induced by acute hyperlipidemia. The findings are consistent with evidence that elevated BP in obese subjects may reflect an imbalance between antioxidant capacity and oxidative stress that is improved by the DASH-CD.
有证据表明，肥胖可能通过氧化应激敏感机制升高血压（BP），而终止高血压膳食方法组合饮食（DASH - CD）可能通过增强抗氧化能力来降低血压。为解决这一问题，对12名肥胖的高正常血压至1期高血压患者（高血压患者）和12名瘦的血压正常者进行了研究，让他们先按平常饮食，然后分别随机依次采用DASH - CD饮食和低抗氧化剂饮食各4周。通过静脉输注脂肪乳剂和肝素4小时诱导急性氧化应激。分别测定血浆铁还原能力（FRAP）和血浆F2 - 异前列腺素作为抗氧化能力和氧化应激的生物标志物。肥胖高血压患者采用DASH - CD饮食时的血压低于平常饮食和低抗氧化剂饮食时（-8.1±1.5 / -7.4±1.6 mmHg，P<0.05）。瘦的血压正常者采用DASH - CD饮食4周后血压无显著变化，但采用低抗氧化剂饮食时血压有升高趋势。平常饮食时，瘦的受试者的FRAP高于肥胖受试者。与平常饮食相比，肥胖志愿者采用DASH - CD饮食时FRAP升高，而瘦的志愿者未升高，且组间差异消失。在低抗氧化剂饮食组中，两组在输注脂肪乳剂和肝素期间F2 - 异前列腺素均从基线水平升高，但采用DASH - CD饮食的肥胖高血压患者未升高。在自由生活的肥胖高血压患者中，DASH - CD饮食可提高抗氧化能力、降低血压并减轻急性高脂血症诱导的氧化应激。这些发现与以下证据一致，即肥胖受试者血压升高可能反映了抗氧化能力与氧化应激之间的失衡，而DASH - CD饮食可改善这种失衡。
