Alizadeh-Navaei R, Rafiei A, Hedayatizadeh-Omran A, Mohammadzadeh I, Arabi M
Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Department of Community Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Ann Med Health Sci Res. 2014 Nov;4(6):837-40. doi: 10.4103/2141-9248.144871.
As environmental factors are important in the development of asthma, genetic factors could have a critical role in the expression of the disease. Hence, we carried out a systematic review to assess the susceptible genes for asthma in Iranian population. We conducted a literature search by using the electronic database PubMed, Biological Abstracts Web of Science, Current Contents Connect, Cinahl, ScienceDirect, Scopus, IranMedex, and Scientific Information Database to identify articles that evaluated the association between genetic variants and the risk of asthma in Iranian population (until April 30, 2012). The search terms were used include: Asthma and gene in combination with Iran for international database. The following criteria were used for selecting literatures in this review: The study should evaluate the association between gene polymorphism and risk of asthma in Iranian population, and the study should be a case-control design with normal subject as ac control group that published in a journal. Finally, 14 case-control studies were extracted from local and international database. In this study, we reviewed 38 polymorphisms in 19 genes. Polymorphism in interleukin-13 (IL-13), IL-10, IL-1, IL-2, IL-12, E-Selectin, S128R and Exon 9 Vitamin D Receptor were susceptible for asthma and polymorphism in chemokine receptor 5, transforming growth factor-a (TGF-a), Intron 8 of the Vitamin D Receptor, angiotensin-converting enzyme gene, IL-6 and interferon-c were not susceptible for asthma in Iranian population. Polymorphism in IL-4, tumor necrosis factor-α and TGF-b had inconsistent findings. This systematic review indicated that three polymorphisms (IL-13, IL-10, and IL-1) are associated with risk of asthma in Iranian population.
由于环境因素在哮喘的发病过程中起着重要作用，遗传因素可能在该疾病的表现中起关键作用。因此，我们进行了一项系统综述，以评估伊朗人群中哮喘的易感基因。我们通过使用电子数据库PubMed、科学网生物学文摘、现刊目次数据库、护理学与健康领域数据库、科学Direct、Scopus、伊朗医学数据库和科学信息数据库进行文献检索，以识别评估伊朗人群中基因变异与哮喘风险之间关联的文章（截至2012年4月30日）。使用的检索词包括：哮喘和基因，以及与伊朗相关的国际数据库。本综述选择文献的标准如下：该研究应评估伊朗人群中基因多态性与哮喘风险之间的关联，且该研究应为以正常受试者作为对照组的病例对照设计，并发表在期刊上。最后，从本地和国际数据库中提取了14项病例对照研究。在本研究中，我们审查了19个基因中的38个多态性。白细胞介素-13（IL-13）、IL-10、IL-1、IL-2、IL-12、E-选择素、S128R和维生素D受体外显子9的多态性易患哮喘，而趋化因子受体5、转化生长因子-α（TGF-α）、维生素D受体内含子8、血管紧张素转换酶基因、IL-6和干扰素-γ的多态性在伊朗人群中不易患哮喘。IL-4、肿瘤坏死因子-α和TGF-β的多态性结果不一致。这项系统综述表明，三种多态性（IL-13、IL-10和IL-1）与伊朗人群的哮喘风险相关。
