Idoate Fernando, Cadore Eduardo L, Casas-Herrero Alvaro, Zambom-Ferraresi Fabricio, Marcellán Teresa, Ruiz de Gordoa Ana, Rodriguez-Mañas Leocadio, Bastarrika Gorka, Marques Mário C, Martínez-Velilla Nicolas, Vicente-Campos Davinia, Izquierdo Mikel
Radiology Department, Clínica San Miguel, Pamplona, Spain.
Eur Radiol. 2015 Jul;25(7):2163-75. doi: 10.1007/s00330-014-3555-5. Epub 2014 Dec 16.
to compare the different adipose tissue (AT) compartments, muscle mass, muscle fat infiltration, coronary calcium, as well as associations among changes in different AT compartments between frail and robust nonagenarians.
Forty-two elderly subjects took part in this study: 29 institutionalized frail elderly (92.0 ± 8 years) and 13 robust elderly (88.2 ± 4.1 years). All patients underwent helical thoracic, abdominal and thigh computed tomography (CT). In addition, a non-enhanced prospectively ECG-triggered cardiac CT was performed to quantify the amount of coronary artery calcification and measure pericardial AT.
The robust group presented significantly greater pericardial and abdominal AT volume, as well as greater axial and appendicular muscle size and high-density muscle tissue (greater muscle quality) than the frail group (P < 0.001), whereas no differences between groups were observed in coronary calcium. There were positive correlations between pericardial AT with visceral and subcutaneous AT values, as well as between pericardial AT and quadriceps, hamstrings, psoas and paravertebral low-density muscle tissues in the frail and robust groups (r = 0.57 to 0.91,P < 0.05).
Robust group presented greater muscle size and quality in the axial and appendicular muscles, as well as pericardial and abdominal AT area than the frail group.
• Robust nonagenarians presented more pericardial and abdominal AT volume than frail. • Frailty is associated with lower muscle size and high-density muscle tissue. • Muscle-fat infiltration shares analogous pattern of visceral and pericardial AT distribution.
比较虚弱与强健的九旬老人不同脂肪组织（AT）区域、肌肉量、肌肉脂肪浸润、冠状动脉钙化情况，以及不同AT区域变化之间的关联。
42名老年受试者参与了本研究：29名入住机构的虚弱老年人（92.0±8岁）和13名强健老年人（88.2±4.1岁）。所有患者均接受了胸部、腹部和大腿螺旋计算机断层扫描（CT）。此外，还进行了非增强前瞻性心电图触发心脏CT，以量化冠状动脉钙化量并测量心包AT。
与虚弱组相比，强健组的心包和腹部AT体积显著更大，轴向和附属肌肉尺寸以及高密度肌肉组织（肌肉质量更高）也更大（P<0.001），而两组之间在冠状动脉钙化方面未观察到差异。在虚弱组和强健组中，心包AT与内脏和皮下AT值之间，以及心包AT与股四头肌、腘绳肌、腰大肌和椎旁低密度肌肉组织之间均存在正相关（r=0.57至0.91，P<0.05）。
与虚弱组相比，强健组在轴向和附属肌肉中的肌肉尺寸和质量更大，心包和腹部AT面积也更大。
• 强健的九旬老人心包和腹部AT体积比虚弱者更多。• 虚弱与较小的肌肉尺寸和高密度肌肉组织有关。• 肌肉脂肪浸润与内脏和心包AT分布模式相似。
