Vreeken J, Hardeman M R, Goedhart P T
Academic Medical Center, Dept. of Internal Medicine, Amsterdam, Netherlands.
Thromb Res. 1989 Jun 15;54(6):733-40. doi: 10.1016/0049-3848(89)90137-0.
In order to evaluate the physiological relevance of the blood platelet "transient aggregation resistance" (TAR) test we studied the effect on this test of two different amounts of fish oil, corresponding to .75 g g (2.5 mmol) and 1.5 g (5 mmol) of eicosapentaenoic acid respectively, added in a cross-over design to the normal diet of 16 healthy male volunteers. It appeared that the "baseline aggregation resistance" (BAR), equivalent to the classic platelet aggregation ADP-threshold, was not influenced by Maxepa while, in contrast, a significant prolongation of TAR occurred. Apparently platelet aggregation analysed early after blood withdrawal, measures aspects of physiological relevance which, due to their short half life, are missed in the original method.
为了评估血小板“短暂聚集抵抗”（TAR）试验的生理相关性，我们采用交叉设计，对16名健康男性志愿者的正常饮食分别添加两种不同量的鱼油（分别相当于0.75克二十碳五烯酸（2.5毫摩尔）和1.5克（5毫摩尔）），研究其对该试验的影响。结果显示，相当于经典血小板聚集ADP阈值的“基线聚集抵抗”（BAR）不受Maxepa影响，而相比之下，TAR显著延长。显然，采血后早期分析的血小板聚集反映了一些生理相关方面，由于其半衰期短，在原始方法中被遗漏。
