Marusiak Jarosław, Żeligowska Ewa, Mencel Joanna, Kisiel-Sajewicz Katarzyna, Majerczak Joanna, Zoladz Jerzy A, Jaskólski Artur, Jaskólska Anna
Department of Kinesiology, Faculty of Physiotherapy, University School of Physical Education in Wroclaw, 51-612 Wroclaw, Poland.
J Rehabil Med. 2015 Apr;47(4):372-5. doi: 10.2340/16501977-1931.
To examine the effects of cycloergometric interval training on parkinsonian rigidity, relaxed biceps brachii muscle tone in affected upper extremities, and serum level of brain-derived neurotrophic factor.
Case series, repeated-measures design, pilot study.
SUBJECTS/PATIENTS: Eleven patients with mild-to-moderate Parkinson's disease (Hoehn & Yahr scale 2.3 ± 0.72), recruited from a neurological clinic, underwent cycle training and were tested along with non-trained, healthy control subjects (n = 11) in a motor control laboratory.
Patients underwent 8 weeks of interval training (3 × 1-h sessions weekly, consisting of a 10-min warm-up, 40 min of interval exercise, and 10-min cool-down) on a stationary cycloergometer. Parkinsonian rigidity (Unified Parkinson's Disease-Rating-Scale) in the upper extremity, resting biceps brachii muscle tone (myometric stiffness and frequency), and brain-derived neurotrophic factor level were measured 1-3 days before interval training cycle started and 6-10 days after the last training session.
Training resulted in a decrease in rigidity (p = 0.048) and biceps brachii myometric muscle stiffness (p = 0.030) and frequency (p = 0.006), and an increase in the level of brain-derived neurotrophic factor (p = 0.035) relative to pre-training values. The increase in brain-derived neurotrophic factor level correlated with improvements in parkinsonian rigidity (p = 0.025), biceps brachii myometric stiffness (p = 0.001) and frequency (p = 0.002).
Training-induced alleviation of parkinsonian rigidity and muscle tone decrease may be associated with neuroplastic changes caused by a training-induced increase in the level of brain-derived neurotrophic factor.
研究循环测力计间歇训练对帕金森病患者上肢僵硬程度、患侧上肢肱二头肌放松时的肌张力以及血清脑源性神经营养因子水平的影响。
病例系列、重复测量设计、初步研究。
受试者/患者：从一家神经科诊所招募了11例轻度至中度帕金森病患者（霍恩和雅尔分级为2.3±0.72），他们接受了自行车训练，并在运动控制实验室与未经训练的健康对照者（n = 11）一起接受测试。
患者在固定的循环测力计上进行为期8周的间歇训练（每周3次，每次1小时，包括10分钟热身、40分钟间歇运动和10分钟冷却）。在间歇训练周期开始前1 - 3天以及最后一次训练 session 后6 - 10天测量上肢帕金森病僵硬程度（统一帕金森病评定量表）、肱二头肌静息肌张力（肌测硬度和频率）以及脑源性神经营养因子水平。
与训练前值相比，训练导致僵硬程度降低（p = 0.048）、肱二头肌肌测肌肉硬度降低（p = 0.030）和频率降低（p = 0.006），以及脑源性神经营养因子水平升高（p = 0.035）。脑源性神经营养因子水平的升高与帕金森病僵硬程度的改善（p = 0.025）、肱二头肌肌测硬度的改善（p = 0.001）和频率的改善（p = 0.002）相关。
训练引起的帕金森病僵硬程度减轻和肌张力降低可能与训练导致的脑源性神经营养因子水平升高所引起的神经可塑性变化有关。
