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本文引用的文献

1
Pharmacokinetic interactions between primaquine and chloroquine.伯氨喹与氯喹之间的药代动力学相互作用。
Antimicrob Agents Chemother. 2014 Jun;58(6):3354-9. doi: 10.1128/AAC.02794-13. Epub 2014 Mar 31.
2
Model system to define pharmacokinetic requirements for antimalarial drug efficacy.定义抗疟药物疗效药代动力学要求的模型系统。
Sci Transl Med. 2013 Oct 2;5(205):205ra135. doi: 10.1126/scitranslmed.3006684.
3
An in vitro repositioning study reveals antifungal potential of chloroquine to inhibit growth and morphogenesis in Candida albicans.
J Gen Appl Microbiol. 2013;59(2):167-70. doi: 10.2323/jgam.59.167.
4
Cell wall perturbation sensitizes fungi to the antimalarial drug chloroquine.细胞壁扰动使真菌对抗疟药物氯喹敏感。
Antimicrob Agents Chemother. 2013 Aug;57(8):3889-96. doi: 10.1128/AAC.00478-13. Epub 2013 Jun 3.
5
Chloroquine sensitizes biofilms of Candida albicans to antifungal azoles.氯喹使白色念珠菌生物膜对抗真菌唑类药物敏感。
Braz J Infect Dis. 2013 Jul-Aug;17(4):395-400. doi: 10.1016/j.bjid.2012.11.002. Epub 2013 Apr 18.
6
Invasive candidiasis in intensive care units in China: a multicentre prospective observational study.中国重症监护病房侵袭性念珠菌病的多中心前瞻性观察研究。
J Antimicrob Chemother. 2013 Jul;68(7):1660-8. doi: 10.1093/jac/dkt083. Epub 2013 Mar 29.
7
Antifungal activity of geldanamycin alone or in combination with fluconazole against Candida species.格尔德霉素单独或与氟康唑联合对念珠菌属真菌的抗真菌活性。
Mycopathologia. 2013 Apr;175(3-4):273-9. doi: 10.1007/s11046-012-9612-1. Epub 2013 Jan 23.
8
In vitro antifungal susceptibility of filamentous fungi causing rare infections: synergy testing of amphotericin B, posaconazole and anidulafungin in pairs.体外抗丝状真菌引起的罕见感染的药敏试验：两性霉素 B、泊沙康唑和安尼白菌素联合药敏试验。
J Antimicrob Chemother. 2012 Aug;67(8):1937-40. doi: 10.1093/jac/dks137. Epub 2012 Apr 25.
9
Epidemiology, species distribution, antifungal susceptibility and outcome of nosocomial candidemia in a tertiary care hospital in Italy.意大利一家三级医院的医院获得性念珠菌血症的流行病学、物种分布、抗真菌药敏性和结局。
PLoS One. 2011;6(9):e24198. doi: 10.1371/journal.pone.0024198. Epub 2011 Sep 15.
10
Pharmacokinetics, pharmacodynamics, and allometric scaling of chloroquine in a murine malaria model.氯喹在小鼠疟疾模型中的药代动力学、药效学和体表面积比例缩放。
Antimicrob Agents Chemother. 2011 Aug;55(8):3899-907. doi: 10.1128/AAC.00067-11. Epub 2011 Jun 6.

氯喹与氟康唑对氟康唑耐药念珠菌属分离株的协同活性。

Synergistic activity of chloroquine with fluconazole against fluconazole-resistant isolates of Candida species.

作者信息

Li Yali, Wan Zhe, Liu Wei, Li Ruoyu

机构信息

Department of Dermatology and Venereology, Peking University First Hospital, Research Center for Medical Mycology, Peking University, and Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Beijing, People's Republic of China.

Department of Dermatology and Venereology, Peking University First Hospital, Research Center for Medical Mycology, Peking University, and Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Beijing, People's Republic of China

出版信息

Antimicrob Agents Chemother. 2015 Feb;59(2):1365-9. doi: 10.1128/AAC.04417-14. Epub 2014 Dec 15.

DOI:10.1128/AAC.04417-14
PMID:25512426
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4335839/
Abstract

The in vitro activity of chloroquine and the interactions of chloroquine combined with fluconazole against 37 Candida isolates were tested using the broth microdilution, disk diffusion, and Etest susceptibility tests. Synergistic effect was detected with 6 of 9 fluconazole-resistant Candida albicans isolates, with Candida krusei ATCC 6258, and with all 12 fluconazole-resistant Candida tropicalis isolates.

摘要

采用肉汤微量稀释法、纸片扩散法和Etest药敏试验，检测了氯喹的体外活性以及氯喹与氟康唑联合应用对37株念珠菌分离株的相互作用。在9株耐氟康唑的白色念珠菌分离株中有6株、克柔念珠菌ATCC 6258以及所有12株耐氟康唑的热带念珠菌分离株中均检测到协同效应。