氯喹与氟康唑对氟康唑耐药念珠菌属分离株的协同活性。
Synergistic activity of chloroquine with fluconazole against fluconazole-resistant isolates of Candida species.
作者信息
Li Yali, Wan Zhe, Liu Wei, Li Ruoyu
机构信息
Department of Dermatology and Venereology, Peking University First Hospital, Research Center for Medical Mycology, Peking University, and Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Beijing, People's Republic of China.
Department of Dermatology and Venereology, Peking University First Hospital, Research Center for Medical Mycology, Peking University, and Beijing Key Laboratory of Molecular Diagnosis of Dermatoses, Beijing, People's Republic of China
出版信息
Antimicrob Agents Chemother. 2015 Feb;59(2):1365-9. doi: 10.1128/AAC.04417-14. Epub 2014 Dec 15.
Abstract
The in vitro activity of chloroquine and the interactions of chloroquine combined with fluconazole against 37 Candida isolates were tested using the broth microdilution, disk diffusion, and Etest susceptibility tests. Synergistic effect was detected with 6 of 9 fluconazole-resistant Candida albicans isolates, with Candida krusei ATCC 6258, and with all 12 fluconazole-resistant Candida tropicalis isolates.
摘要
采用肉汤微量稀释法、纸片扩散法和Etest药敏试验，检测了氯喹的体外活性以及氯喹与氟康唑联合应用对37株念珠菌分离株的相互作用。在9株耐氟康唑的白色念珠菌分离株中有6株、克柔念珠菌ATCC 6258以及所有12株耐氟康唑的热带念珠菌分离株中均检测到协同效应。
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