阿尼芬净对2500多株念珠菌临床分离株的体外活性，其中包括315株对氟康唑耐药的分离株。
In vitro activities of anidulafungin against more than 2,500 clinical isolates of Candida spp., including 315 isolates resistant to fluconazole.
作者信息
Pfaller M A, Boyken L, Hollis R J, Messer S A, Tendolkar S, Diekema D J
机构信息
Medical Microbiology Division, C606 GH, Department of Pathology, University of Iowa College of Medicine, Iowa City, IA 52242, USA.
出版信息
J Clin Microbiol. 2005 Nov;43(11):5425-7. doi: 10.1128/JCM.43.11.5425-5427.2005.
Anidulafungin is an echinocandin antifungal agent with potent activity against Candida spp. We assessed the in vitro activity of anidulafungin against 2,235 clinical isolates of Candida spp. using the CLSI broth microdilution method. Anidulafungin was very active against Candida spp. (the MIC at which 90% of strains are inhibited [MIC(90)] was 2 microg/ml when MIC endpoint criteria of partial inhibition [MIC-2] were used). Candida albicans, C. glabrata, C. tropicalis, C. krusei, and C. kefyr were the most susceptible species of Candida (MIC(90), 0.06 to 0.12 microg/ml), and C. parapsilosis, C. lusitaniae, and C. guilliermondii were the least susceptible (MIC(90), 0.5 to 2 microg/ml). In addition, 315 fluconazole-resistant isolates were tested, and 99% were inhibited by < or =1 microg/ml of anidulafungin. These results provide further evidence for the spectrum and potency of anidulafungin activity against a large and geographically diverse collection of clinically important isolates of Candida spp.
阿尼芬净是一种棘白菌素类抗真菌药物，对念珠菌属具有强大活性。我们采用美国临床和实验室标准协会（CLSI）肉汤微量稀释法评估了阿尼芬净对2235株念珠菌临床分离株的体外活性。阿尼芬净对念珠菌属活性很强（当使用部分抑制的MIC终点标准[MIC-2]时，90%菌株被抑制的MIC[MIC(90)]为2微克/毫升）。白色念珠菌、光滑念珠菌、热带念珠菌、克柔念珠菌和凯菲念珠菌是念珠菌中最敏感的菌种（MIC(90)，0.06至0.12微克/毫升），而近平滑念珠菌、葡萄牙念珠菌和季也蒙念珠菌最不敏感（MIC(90)，0.5至2微克/毫升）。此外，对315株氟康唑耐药分离株进行了测试，99%的菌株被≤1微克/毫升的阿尼芬净抑制。这些结果为阿尼芬净针对大量地理分布多样的临床重要念珠菌分离株的活性谱和效力提供了进一步证据。
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