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Rebuttal from Michael B. Reid, Andrew R. Judge and Sue C. Bodine.迈克尔·B·里德、安德鲁·R·贾奇和苏·C·博迪内的反驳意见。
J Physiol. 2014 Dec 15;592(24):5351. doi: 10.1113/jphysiol.2014.284398.
2
CrossTalk proposal: The dominant mechanism causing disuse muscle atrophy is decreased protein synthesis.相互作用假说：导致废用性肌肉萎缩的主要机制是蛋白质合成减少。
J Physiol. 2014 Dec 15;592(24):5341-3. doi: 10.1113/jphysiol.2014.273615.
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Not all disuse protocols are equal: new insight into the signalling pathways to muscle atrophy.并非所有的废用方案都是相同的：对肌肉萎缩信号通路的新见解。
J Physiol. 2015 Dec 15;593(24):5227-8. doi: 10.1113/JP271613.
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CrossTalk opposing view: The dominant mechanism causing disuse muscle atrophy is proteolysis.相互矛盾的观点：导致废用性肌肉萎缩的主要机制是蛋白水解。
J Physiol. 2014 Dec 15;592(24):5345-7. doi: 10.1113/jphysiol.2014.279406.
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Newton's force as countermeasure for disuse atrophy.牛顿力作为废用性萎缩的应对措施。
J Appl Physiol (1985). 2009 Jul;107(1):6-7. doi: 10.1152/japplphysiol.00499.2009. Epub 2009 May 14.
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Rebuttal from Stuart M. Phillips and Chris McGlory.斯图尔特·M·菲利普斯和克里斯·麦格洛里的反驳。
J Physiol. 2014 Dec 15;592(24):5349. doi: 10.1113/jphysiol.2014.284406.
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Nutritional strategies to attenuate muscle disuse atrophy.减轻肌肉废用性萎缩的营养策略。
Nutr Rev. 2013 Apr;71(4):195-208. doi: 10.1111/nure.12019. Epub 2013 Feb 28.
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Alterations of protein turnover underlying disuse atrophy in human skeletal muscle.人类骨骼肌废用性萎缩背后蛋白质周转的改变。
J Appl Physiol (1985). 2009 Sep;107(3):645-54. doi: 10.1152/japplphysiol.00452.2009. Epub 2009 Jul 16.
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Muscle disuse atrophy is not accompanied by changes in skeletal muscle satellite cell content.肌肉废用性萎缩并不伴有骨骼肌卫星细胞含量的变化。
Clin Sci (Lond). 2014 Apr;126(8):557-66. doi: 10.1042/CS20130295.
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Disuse-induced preferential loss of the giant protein titin depresses muscle performance via abnormal sarcomeric organization.废用诱导的巨大蛋白质肌联蛋白优先丧失通过异常的肌节组织降低肌肉性能。
J Gen Physiol. 2008 Jan;131(1):33-41. doi: 10.1085/jgp.200709888.
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High-Intensity Aerobic Exercise Prevents Angiotensin II-Induced Muscle Atrophy.高强度有氧运动可预防血管紧张素 II 诱导的肌肉萎缩。
Int Neurourol J. 2025 Jul;29(Suppl 1):S44-S52. doi: 10.5213/inj.2550150.075. Epub 2025 Jul 31.
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Mechanisms of exercise as a preventative measure to muscle wasting.运动作为预防肌肉减少的措施的机制。
Am J Physiol Cell Physiol. 2021 Jul 1;321(1):C40-C57. doi: 10.1152/ajpcell.00056.2021. Epub 2021 May 5.
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Muscle-specific and age-related changes in protein synthesis and protein degradation in response to hindlimb unloading in rats.大鼠后肢卸载后肌肉特异性及与年龄相关的蛋白质合成和蛋白质降解变化。
J Appl Physiol (1985). 2017 May 1;122(5):1336-1350. doi: 10.1152/japplphysiol.00703.2016. Epub 2017 Mar 23.
4
Protecting Skeletal Muscle with Protein and Amino Acid during Periods of Disuse.在废用期间用蛋白质和氨基酸保护骨骼肌。
Nutrients. 2016 Jul 1;8(7):404. doi: 10.3390/nu8070404.
本文引用的文献
1
Substantial skeletal muscle loss occurs during only 5 days of disuse.仅在 5 天的不活动期间就会发生大量骨骼肌损失。
Acta Physiol (Oxf). 2014 Mar;210(3):600-11. doi: 10.1111/apha.12190. Epub 2013 Dec 5.
2
Calpain and caspase-3 play required roles in immobilization-induced limb muscle atrophy.钙蛋白酶和半胱天冬酶-3 在固定引起的肢体肌肉萎缩中发挥必需作用。
J Appl Physiol (1985). 2013 May 15;114(10):1482-9. doi: 10.1152/japplphysiol.00925.2012. Epub 2013 Mar 7.
3
Diaphragm muscle thinning in patients who are mechanically ventilated.机械通气患者的膈肌变薄。
Chest. 2012 Dec;142(6):1455-1460. doi: 10.1378/chest.11-1638.
4
Aging affects the transcriptional regulation of human skeletal muscle disuse atrophy.衰老影响人类骨骼肌废用性萎缩的转录调控。
PLoS One. 2012;7(12):e51238. doi: 10.1371/journal.pone.0051238. Epub 2012 Dec 19.
5
Heterogeneous atrophy occurs within individual lower limb muscles during 60 days of bed rest.卧床休息 60 天期间，个体下肢肌肉会出现异质性萎缩。
J Appl Physiol (1985). 2012 Nov;113(10):1545-59. doi: 10.1152/japplphysiol.00611.2012. Epub 2012 Sep 13.
6
The time course of the adaptations of human muscle proteome to bed rest and the underlying mechanisms.人类肌肉蛋白质组对卧床休息的适应过程及其潜在机制。
J Physiol. 2012 Oct 15;590(20):5211-30. doi: 10.1113/jphysiol.2012.240267. Epub 2012 Jul 30.
7
A longitudinal MRI study of muscle atrophy during lower leg immobilization following ankle fracture.踝关节骨折后小腿固定期间肌肉萎缩的纵向 MRI 研究。
J Magn Reson Imaging. 2012 Mar;35(3):686-95. doi: 10.1002/jmri.22864. Epub 2011 Nov 1.
8
Prevention of muscle disuse atrophy by MG132 proteasome inhibitor.通过 MG132 蛋白酶体抑制剂预防肌肉废用性萎缩。
Muscle Nerve. 2011 May;43(5):708-16. doi: 10.1002/mus.21949. Epub 2011 Apr 1.
9
Prolonged space flight-induced alterations in the structure and function of human skeletal muscle fibres.人类骨骼肌纤维的结构和功能在长期太空飞行诱导下发生的改变。
J Physiol. 2010 Sep 15;588(Pt 18):3567-92. doi: 10.1113/jphysiol.2010.188508. Epub 2010 Jul 26.
10
Differential atrophy of the lower-limb musculature during prolonged bed-rest.下肢肌肉在长期卧床休息期间出现差异萎缩。
Eur J Appl Physiol. 2009 Nov;107(4):489-99. doi: 10.1007/s00421-009-1136-0. Epub 2009 Aug 13.
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