一种用于研究高强度聚焦超声对动脉瘤影响的显微外科分叉部兔模型：技术说明

A microsurgical bifurcation rabbit model to investigate the effect of high-intensity focused ultrasound on aneurysms: a technical note.

作者信息

Coluccia Daniel, Fandino Javier, Marbacher Serge, Erhardt Salome, Kienzler Jenny, Martin Ernst, Werner Beat

机构信息

Department of Neurosurgery, Kantonsspital Aarau, Tellstrasse, 5001 Aarau, Switzerland ; Cerebrovascular Research Laboratory, Department of Intensive Care Medicine, University of Bern and Bern University Hospital, Bern, Switzerland.

Center for MR Research, University Children's Hospital, Zürich, Switzerland.

出版信息

J Ther Ultrasound. 2014 Oct 31;2:21. doi: 10.1186/2050-5736-2-21. eCollection 2014.

DOI:10.1186/2050-5736-2-21

PMID:25512871

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4265988/

Abstract

BACKGROUND

Recent clinical studies confirmed the high potential of MR-guided focused ultrasound (MRgFUS) in the field of functional neurosurgery. While its ability for precise thermo-ablation within soft tissue is widely recognized, the impact of high-intensity focused ultrasound (HIFU) on larger vessels is less explored. We used a bifurcation aneurysm model in rabbits to investigate the possible effects on the walls of vascular aneurysms and to assess the risk and prospect of this procedure for managing neurovascular disorders.

METHODS

Experimental bifurcation aneurysms were microsurgically created in New Zealand white rabbits and sonicated using MRgFUS.

RESULTS

A temperature of max. 54°C could be achieved close to the aneurysm, and the shape and size of the aneurysm were noticeably changed, as shown by MR angiography.

CONCLUSIONS

The presented rabbit model proved suitable and capable of being extended to acquire data on the effect of HIFU on aneurysms and larger vessels. The fact that HIFU led to an alteration of the aneurysm without inducing rupture encourages further investigations.

摘要