Coluccia Daniel, Fandino Javier, Marbacher Serge, Erhardt Salome, Kienzler Jenny, Martin Ernst, Werner Beat
Department of Neurosurgery, Kantonsspital Aarau, Tellstrasse, 5001 Aarau, Switzerland ; Cerebrovascular Research Laboratory, Department of Intensive Care Medicine, University of Bern and Bern University Hospital, Bern, Switzerland.
Center for MR Research, University Children's Hospital, Zürich, Switzerland.
J Ther Ultrasound. 2014 Oct 31;2:21. doi: 10.1186/2050-5736-2-21. eCollection 2014.
Recent clinical studies confirmed the high potential of MR-guided focused ultrasound (MRgFUS) in the field of functional neurosurgery. While its ability for precise thermo-ablation within soft tissue is widely recognized, the impact of high-intensity focused ultrasound (HIFU) on larger vessels is less explored. We used a bifurcation aneurysm model in rabbits to investigate the possible effects on the walls of vascular aneurysms and to assess the risk and prospect of this procedure for managing neurovascular disorders.
Experimental bifurcation aneurysms were microsurgically created in New Zealand white rabbits and sonicated using MRgFUS.
A temperature of max. 54°C could be achieved close to the aneurysm, and the shape and size of the aneurysm were noticeably changed, as shown by MR angiography.
The presented rabbit model proved suitable and capable of being extended to acquire data on the effect of HIFU on aneurysms and larger vessels. The fact that HIFU led to an alteration of the aneurysm without inducing rupture encourages further investigations.
近期临床研究证实了磁共振引导聚焦超声（MRgFUS）在功能神经外科领域具有很高的潜力。虽然其在软组织内进行精确热消融的能力已得到广泛认可，但高强度聚焦超声（HIFU）对较大血管的影响研究较少。我们使用兔分叉动脉瘤模型来研究其对血管动脉瘤壁的可能影响，并评估该手术治疗神经血管疾病的风险和前景。
在新西兰白兔身上显微手术创建实验性分叉动脉瘤，并用MRgFUS进行超声处理。
靠近动脉瘤处可达到最高54°C的温度，磁共振血管造影显示动脉瘤的形状和大小有明显变化。
所呈现的兔模型被证明是合适的，并且能够扩展以获取关于HIFU对动脉瘤和较大血管影响的数据。HIFU导致动脉瘤改变而未引发破裂这一事实鼓励进一步研究。
