1 Paediatric Endocrinology Department, Mafraq Hospital , AbuDhabi, United Arab Emirates .
Diabetes Technol Ther. 2015 Mar;17(3):166-70. doi: 10.1089/dia.2014.0224. Epub 2014 Dec 16.
Insulin pumps are equipped with advanced functions. Intensive training and adherence are required for optimum use of the technology. We aimed to assess the association of various key elements in insulin pump functions on blood glucose control.
Patients on insulin pump therapy were enrolled. Insulin pumps were downloaded (CareLink(®) Pro 3 software; Medtronic Minimed, Northridge, CA), and data were collected over an 8-12-week period. Glycemic control of patients was classified as controlled (hemoglobin A1c [HbA1c] level of 7.5% or less in adults and 8% or less in children) and uncontrolled based on HbA1c level at enrollment. Variables studied were use of sensors and duration, frequency of blood glucose monitoring, Bolus Wizard (Medtronic Minimed) use, frequency of correction boluses, and frequency of cannula changing.
Seventy-two patients were enrolled (50 children). Median age was 12 years for children and 27.5 years for adults. Respective median numbers of blood glucose checks were 4.4 and 3.2 for controlled and uncontrolled children (P<0.021) and 3.1 and 2.8 for controlled and uncontrolled adults, respectively. Respective frequency of Bolus Wizard use per day showed a median of 6 and 4.15 for controlled and uncontrolled children (P<0.001) and 3.8 and 3.5 for controlled and uncontrolled adults. Controlled children wore sensors for longer (5 vs. 2.9 days/week) and did more corrections (3.9 vs. 2.5). There was no difference in the frequency of changing the infusion cannula in children's or adults' groups.
We conclude that the frequency of blood glucose monitoring and Bolus Wizard use have a favorable association with glycemic control. These observations were more significant in the children's groups. Our data shows that patients with better control tend to bolus more for correction and wear sensors longer.
胰岛素泵配备了先进的功能。为了最佳地使用这项技术，需要进行强化培训并保持依从性。我们旨在评估胰岛素泵功能的各种关键要素与血糖控制之间的关系。
招募接受胰岛素泵治疗的患者。下载胰岛素泵数据（CareLink®Pro 3 软件；美敦力迷你美迪，加利福尼亚州北岭），并在 8-12 周的时间内收集数据。根据入组时的糖化血红蛋白（HbA1c）水平，将患者的血糖控制情况分为控制良好（HbA1c 水平成人<7.5%，儿童<8%）和控制不佳。研究的变量包括传感器的使用和持续时间、血糖监测频率、Bolus Wizard（美敦力迷你美迪）的使用、校正性推注的频率以及导管更换的频率。
共纳入 72 例患者（50 例儿童）。儿童的中位年龄为 12 岁，成人的中位年龄为 27.5 岁。控制良好和控制不佳的儿童分别有 4.4 和 3.2 次/天的中位血糖检查（P<0.021），控制良好和控制不佳的成人分别有 3.1 和 2.8 次/天的中位血糖检查。控制良好的儿童每天使用 Bolus Wizard 的中位数为 6 次，控制不佳的儿童为 4.15 次（P<0.001），控制良好的成人和控制不佳的成人分别为 3.8 次和 3.5 次。控制良好的儿童佩戴传感器的时间更长（每周 5 天 vs. 2.9 天），校正次数更多（3.9 次 vs. 2.5 次）。儿童和成人组中输注导管更换的频率没有差异。
我们的结论是，血糖监测和 Bolus Wizard 使用的频率与血糖控制有良好的相关性。在儿童组中，这些观察结果更为显著。我们的数据表明，控制良好的患者倾向于进行更多的校正性推注，并佩戴更长时间的传感器。
