Huh Joo Young, Siopi Aikaterina, Mougios Vassilis, Park Kyung Hee, Mantzoros Christos S
Division of Endocrinology, Diabetes, and Metabolism (J.Y.H., K.H.P., C.S.M.), Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215; School of Physical Education and Sports Science (A.S., V.M.), Aristotle University of Thessaloniki, Thessaloniki 54124, Greece; Department of Family Medicine (K.H.P.), Hallym University Sacred Heart Hospital, Hallym University, Gyeonggi-do 431-796, Korea; and Section of Endocrinology (C.S.M.), Boston VA Healthcare System, Harvard Medical School, Boston, Massachusetts 02130.
J Clin Endocrinol Metab. 2015 Mar;100(3):E453-7. doi: 10.1210/jc.2014-2416. Epub 2014 Dec 16.
Irisin is a recently identified exercise-induced myokine. However, the circulating levels of irisin in response to different types of exercise in subjects with metabolic syndrome are unknown.
This study aimed to study the levels of irisin in healthy males and subjects with metabolic syndrome at baseline and in response to exercise.
Each individual completed high-intensity interval exercise (HIIE), continuous moderate-intensity exercise (CME), and resistance exercise (RE) sessions in a random, crossover design. Percentage change in circulating irisin levels was examined. Two different irisin assays were used to compare the results of the RE study.
Circulating irisin increased immediately after HIIE, CME, and RE and declined 1 hour later. The increase was greater in response to resistance compared with either high-intensity intermittent exercise or CME. Change in irisin in response to exercise did not differ between individuals with and without metabolic syndrome.
Exercise is able to increase circulating irisin levels in individuals with the metabolic syndrome as well as healthy individuals. Whether this increase may contribute to the beneficial effects of exercise on patients with the metabolic syndrome remains to be studied further.
鸢尾素是最近发现的一种运动诱导的肌动蛋白。然而，代谢综合征患者对不同类型运动的鸢尾素循环水平尚不清楚。
本研究旨在研究健康男性和代谢综合征患者在基线时以及运动后的鸢尾素水平。
采用随机交叉设计，每位受试者完成高强度间歇运动（HIIE）、持续中等强度运动（CME）和抗阻运动（RE）训练。检测循环鸢尾素水平的百分比变化。使用两种不同的鸢尾素检测方法比较RE研究的结果。
HIIE、CME和RE后循环鸢尾素立即升高，1小时后下降。与高强度间歇运动或CME相比，抗阻运动后的升高幅度更大。有代谢综合征和无代谢综合征的个体在运动后鸢尾素的变化无差异。
运动能够提高代谢综合征患者和健康个体的循环鸢尾素水平。这种升高是否有助于运动对代谢综合征患者的有益作用仍有待进一步研究。
