Cordingley Dean M, Anderson Judy E, Cornish Stephen M
Applied Health Sciences, University of Manitoba, Winnipeg, MB R3T 2N2 Canada.
Pan Am Clinic Foundation, 75 Poseidon Bay, Winnipeg, MB R3M 3E4 Canada.
J Sci Sport Exerc. 2022 May 13:1-15. doi: 10.1007/s42978-022-00164-2.
The purpose of this study was to examine the response of myokines to blood-flow restricted resistance-exercise (BFR-RE) in younger and older males before and after completing a 12-week resistance-training program.
There were 8 younger (24.8 ± 3.9 yrs) and 7 older (68.3 ± 5.0 yrs) untrained male participants completed this study. Anthropometric and maximal strength (1RM) measurements were collected before and after a 12-week, supervised, progressive full-body resistance-training program. As well, an acute bout of full-body BFR-RE was performed with venipuncture blood samples collected before and immediately following the BFR-RE, followed by sampling at 3, 6, 24 and 48 h.
The 12-week training program stimulated a 32.2% increase in average strength and 30% increase in strength per kg of fat free mass. The response of particular myokines to the acute bout of BFR-RE was influenced training status (IL-4, untrained = 78.1 ± 133.2 pg/mL vs. trained = 59.8 ± 121.6 pg/mL, = 0.019; IL-7, untrained = 3.46 ± 1.8 pg/mL vs. trained = 2.66 ± 1.3 pg/mL, = 0.047) or both training and age (irisin, = 0.04; leukemia inhibitory factor, < 0.001). As well, changes in strength per kg of fat free mass were correlated with area under the curve for IL-4 ( = 0.537; = 0.039), IL-6 ( = 0. 525; = 0.044) and LIF ( = - 0.548; = 0.035) in the untrained condition.
This study identified that both age and training status influence the myokine response to an acute bout of BFR-RE with the release of IL-4, IL-6 and LIF in the untrained state being associated with changes in strength per kg of fat free mass.
本研究旨在探讨年轻男性和老年男性在完成12周抗阻训练计划前后，肌动蛋白对血流限制抗阻运动（BFR-RE）的反应。
8名年轻（24.8±3.9岁）和7名老年（68.3±5.0岁）未经训练的男性参与者完成了本研究。在一项为期12周、有监督的、渐进式全身抗阻训练计划前后，收集人体测量数据和最大力量（1RM）测量值。此外，进行了一次急性全身BFR-RE，并在BFR-RE之前和之后立即采集静脉血样，随后在3、6、24和48小时进行采样。
为期12周的训练计划使平均力量增加了32.2%，每千克去脂体重的力量增加了30%。特定肌动蛋白对急性BFR-RE发作的反应受训练状态（IL-4，未训练者=78.1±133.2 pg/mL，训练者=59.8±121.6 pg/mL，P=0.019；IL-7，未训练者=3.46±1.8 pg/mL，训练者=2.66±1.3 pg/mL，P=0.047）或训练状态和年龄两者的影响（鸢尾素，P=0.04；白血病抑制因子，P<0.001）。此外，在未训练状态下，每千克去脂体重的力量变化与IL-4（P=0.537；P=0.039）、IL-6（P=0.525；P=0.044）和白血病抑制因子（P=-0.548；P=0.035）的曲线下面积相关。
本研究发现，年龄和训练状态均会影响肌动蛋白对急性BFR-RE发作的反应，在未训练状态下，IL-4、IL-6和白血病抑制因子的释放与每千克去脂体重的力量变化相关。
