Mohammed Sumaya Nadhim, Jasim Mohannad Hamid, Mahmood Shahad Hisham, Saleh Eman Naji, Hashemzadeh Alireza
Medical Laboratory Techniques Department, College of Health and Medical Technology, University of Al-Maarif, Anbar, Iraq.
Biology Department, College of Education, University of Fallujah, Fallujah, Iraq.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Apr 1. doi: 10.1007/s00210-025-04083-1.
Irisin, a myokine released during physical exercise, has emerged as a key mediator of muscle health and metabolic regulation. This review synthesizes current evidence on how aerobic exercise stimulates irisin release and its subsequent effects, including enhanced muscle mass, strength, and recovery. Additionally, irisin promotes the browning of white adipose tissue, improving fat metabolism and glucose regulation. These adaptations position irisin as a promising therapeutic target for preventing metabolic disorders and optimizing exercise protocols. By exploring human studies and mechanistic insights, this review underscores irisin's potential to address global health challenges, such as obesity and type 2 diabetes, while advancing strategies for personalized exercise interventions.
鸢尾素是一种在体育锻炼过程中释放的肌动蛋白，已成为肌肉健康和代谢调节的关键介质。本综述综合了当前关于有氧运动如何刺激鸢尾素释放及其后续影响的证据，包括增加肌肉质量、力量和恢复能力。此外，鸢尾素可促进白色脂肪组织的褐变，改善脂肪代谢和血糖调节。这些适应性变化使鸢尾素成为预防代谢紊乱和优化运动方案的有前景的治疗靶点。通过探索人体研究和机制见解，本综述强调了鸢尾素在应对肥胖和2型糖尿病等全球健康挑战方面的潜力，同时推进个性化运动干预策略。
