Wells Jack A, Holmes Holly E, O'Callaghan James M, Colgan Niall, Ismail Ozama, Fisher Elizabeth Mc, Siow Bernard, Murray Tracey K, Schwarz Adam J, O'Neill Michael J, Collins Emily C, Lythgoe Mark F
UCL Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK.
Department of Neurodegenerative Disease, Institute of Neurology, UCL, London, UK.
J Cereb Blood Flow Metab. 2015 Mar;35(3):359-62. doi: 10.1038/jcbfm.2014.224. Epub 2014 Dec 17.
Vascular abnormalities are a key feature of Alzheimer's disease (AD). Imaging of cerebral vascular reactivity (CVR) is a powerful tool to investigate vascular health in clinical populations although the cause of reduced CVR in AD patients is not fully understood. We investigated the specific role of tau pathology in CVR derangement in AD using the rTg4510 mouse model. We observed an increase in CVR in cortical regions with tau pathology. These data suggest that tau pathology alone does not produce the clinically observed decreases in CVR and implicates amyloid pathology as the dominant etiology of impaired CVR in AD patients.
血管异常是阿尔茨海默病（AD）的一个关键特征。尽管AD患者脑血管反应性（CVR）降低的原因尚未完全明确，但脑血管反应性成像仍是研究临床人群血管健康的有力工具。我们使用rTg4510小鼠模型研究了tau病理在AD患者CVR紊乱中的具体作用。我们观察到存在tau病理的皮质区域CVR增加。这些数据表明，仅tau病理不会导致临床上观察到的CVR降低，提示淀粉样蛋白病理是AD患者CVR受损的主要病因。
