Guan Yongjuan, Liang Guanxiang, Hawken Penny A R, Meachem Sarah J, Malecki Irek A, Ham Seungmin, Stewart Tom, Guan Le Luo, Martin Graeme B
Reprod Fertil Dev. 2014 Dec 17. doi: 10.1071/RD14368.
We tested whether the reversible effects of nutrition on spermatogenesis in sexually mature sheep were mediated by Sertoli cells. Rams were fed with diets designed to achieve a 10% increase (High), no change (Maintenance) or a 10% decrease (Low) in body mass after 65 days. At the end of treatment, testes were lighter in the Low than the High group (PP<0.05) in the expression of seven Sertoli cell-specific genes. Under-nutrition appeared to reverse cellular differentiation leading to disruption of tight-junction morphology. In conclusion, in sexually mature sheep, reversible reductions in testis mass and spermatogenesis caused by under-nutrition were associated with impairment of basic aspects of Sertoli cell function but not with changes in the number of Sertoli cells.
我们测试了营养对性成熟绵羊精子发生的可逆影响是否由支持细胞介导。给公羊喂食旨在使体重在65天后增加10%（高营养组）、无变化（维持组）或减少10%（低营养组）的日粮。在处理结束时，低营养组的睾丸重量比高营养组轻（P<0.05），在七个支持细胞特异性基因的表达方面也是如此。营养不足似乎逆转了细胞分化，导致紧密连接形态破坏。总之，在性成熟绵羊中，营养不足导致的睾丸重量和精子发生的可逆性降低与支持细胞功能基本方面的损害有关，但与支持细胞数量的变化无关。
