mTORC1 抓取高尔基体。
mTORC1 gRABs the Golgi.
机构信息
Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA.
Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA.
出版信息
Cancer Cell. 2014 Nov 10;26(5):601-3. doi: 10.1016/j.ccell.2014.10.011.
A lysosome-based mechanism of amino acid sensing by mTORC1 regulated by Rag GTPases has emerged. In this issue of Cancer Cell, Thomas and colleagues propose a Golgi-based and Rag-independent mechanism mediated by the Rab1A GTPase. Furthermore, Rab1A overexpression in colorectal cancers correlates with mTORC1 activity and sensitivity to mTOR inhibitors.
一种由 Rag GTPases 调控的 mTORC1 通过溶酶体感知氨基酸的机制已经出现。在本期《癌细胞》中，Thomas 及其同事提出了一种由 Rab1A GTPase 介导的、不依赖于高尔基体和 Rag 的机制。此外，结直肠癌中 Rab1A 的过表达与 mTORC1 的活性和对 mTOR 抑制剂的敏感性相关。
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