Villarino Romero Rodrigo, Osicka Radim, Sebo Peter
Institute of Microbiology of the Academy of Sciences of the Czech Republic, v.v.i., Videnska 1083, 142 20 Prague, Czech Republic.
Future Microbiol. 2014;9(12):1339-60. doi: 10.2217/fmb.14.77.
The filamentous hemagglutinin of pathogenic Bordetellae is a prototype of a large two-partner-system-secreted and β-structure-rich bacterial adhesin. It exhibits several binding activities that may facilitate bacterial adherence to airway mucosa and host phagocytes in the initial phases of infection. Despite three decades of research on filamentous hemagglutinin, there remain many questions on its structure-function relationships, integrin interactions and possible immunomodulatory signaling capacity. Here we review the state of knowledge on this important virulence factor and acellular pertussis vaccine component. Specific emphasis is placed on outstanding questions that are yet to be answered.
致病性博德特氏菌的丝状血凝素是一种大型双组分系统分泌且富含β结构的细菌粘附素的原型。它具有多种结合活性，在感染初期可能有助于细菌粘附到气道粘膜和宿主吞噬细胞上。尽管对丝状血凝素进行了三十年的研究，但关于其结构-功能关系、整合素相互作用以及可能的免疫调节信号传导能力仍存在许多问题。在此，我们综述了关于这一重要毒力因子和无细胞百日咳疫苗成分的知识现状。特别强调了尚未得到解答的突出问题。
