Matsuo Hidenori
Nihon Rinsho. 2014 Nov;72(11):1999-2002.
In acute phase of multiple sclerosis (MS) and neuromyelitis optica (NMO), plasmapheresis (PP) should be considered as the 2nd choice treatment when corticosteroid pulse therapy results in unsuccessful. It is believed that the beneficial effects of PP occur through the elimination of pathogenic humoral and plasma factors, including autoantibodies, complement components, and cytokines. In MS, several clinical trials have shown the efficacy. However, there have been no randomized controlled trials that demonstrated the efficacy of PP in NMO. There are three methods of PP, plasma exchange, double filtration plasmapheresis and immunoadsorption plasmapheresis, available in Japan. But the difference of efficacy among these 3 methods has not been fully evaluated.
在多发性硬化症（MS）和视神经脊髓炎（NMO）的急性期，当皮质类固醇脉冲疗法效果不佳时，血浆置换（PP）应被视为第二选择的治疗方法。据信，PP的有益效果是通过清除致病性体液和血浆因子，包括自身抗体、补体成分和细胞因子来实现的。在MS中，多项临床试验已证明其疗效。然而，尚无随机对照试验证明PP在NMO中的疗效。在日本，有三种PP方法可供使用，即血浆置换、双重滤过血浆置换和免疫吸附血浆置换。但这三种方法之间疗效的差异尚未得到充分评估。
