Srp Arh Celok Lek. 2014 Sep-Oct;142(9-10):542-6. doi: 10.2298/sarh1410542p.
Pulmonary artery stenosis (PS) is a congenital heart defect which occurs in 10% of all congenital heart defects. Pulmonary balloon valvuloplasty (BVP) has been the treatment of choice of PS over the last 30 years.
The purpose of this study was to evaluate the effi- cacy of this method based on middle-term hospital follow-up, and safety of BVP based on our experience.
The study included 88 patients diagnosed with PS.The patients were divided into three groups based on the severity of the disease. Also, they were divided into two age groups in order to analyze the frequency of complications. Hemodynamic measurements and echocardiography results were recorded before, 24-36 hours after BVP and at the end of follow-up.
The studied group involved patients of average age 3.75 ± 4.3 years (20 days to 17 years). Immediately after BVP a significant decrease of pressure gradient across the pulmonary valve (PV) was recorded in all patients; this result was similar in all 3 groups of patients regardless of the severity of stenosis (p < 0.001). Complications of BVP occurred most commonly in children up to 12 months of age (ventricular tachycardia 4.5% and supraventricular tachycardia 6.8%). Pulmonary valve in- sufficiency after dilatation occurred in 6.6% of cases, and was most common in children aged up to 12 months. In 87 (98.9%) patients BVP was a definitive solution, and a significant residual stenosis was not recorded during follow-up.
BVP is a safe and effective procedure in the treatment of isolated PS in children, regardless of the severity of stenosis but also regardless of patients' age.
肺动脉狭窄(PS)是一种先天性心脏缺陷,在所有先天性心脏缺陷中发生率为10%。在过去30年里,肺动脉球囊瓣膜成形术(BVP)一直是PS的首选治疗方法。
本研究旨在基于中期医院随访评估该方法的疗效,并根据我们的经验评估BVP的安全性。
该研究纳入了88例诊断为PS的患者。根据疾病严重程度将患者分为三组。此外,为分析并发症发生频率,将患者分为两个年龄组。在BVP术前、术后24 - 36小时以及随访结束时记录血流动力学测量结果和超声心动图结果。
研究组患者平均年龄为3.75±4.3岁(20天至17岁)。BVP术后即刻,所有患者肺动脉瓣(PV)跨瓣压差均显著降低;无论狭窄严重程度如何,所有3组患者的这一结果均相似(p<0.001)。BVP并发症最常发生于年龄在12个月以下的儿童(室性心动过速4.5%,室上性心动过速6.8%)。扩张后肺动脉瓣关闭不全发生率为6.6%,最常见于12个月以下儿童。87例(98.9%)患者BVP是最终解决方案,随访期间未记录到明显残余狭窄。
BVP是治疗儿童孤立性PS安全有效的方法,无论狭窄严重程度如何,也无论患者年龄大小。