Rathod Anita, Bonny Olivier, Guessous Idris, Suter Paolo M, Conen David, Erne Paul, Binet Isabelle, Gabutti Luca, Gallino Augusto, Muggli Franco, Hayoz Daniel, Péchère-Bertschi Antoinette, Paccaud Fred, Burnier Michel, Bochud Murielle
Due to the number of contributing authors, the affiliations are provided in the Supplemental Material.
Clin J Am Soc Nephrol. 2015 Mar 6;10(3):452-62. doi: 10.2215/CJN.12511213. Epub 2014 Dec 17.
Population-based data on urinary calcium excretion are scarce. The association of serum calcium and circulating levels of vitamin D [25(OH)D2 or D3] with urinary calcium excretion in men and women from a population-based study was explored.
DESIGN, SETTINGS, PARTICIPANTS, & MEASUREMENTS: Multivariable linear regression was used to explore factors associated with square root-transformed 24-hour urinary calcium excretion (milligrams per 24 hours) taken as the dependent variable with a focus on month-specific vitamin D tertiles and serum calcium in the Swiss Survey on Salt Study.
In total, 624 men and 669 women were studied with mean ages of 49.2 and 47.0 years, respectively (age range=15-95 years). Mean urinary calcium excretion was higher in men than in women (183.05 versus 144.60 mg/24 h; P<0.001). In adjusted models, the association (95% confidence interval) of square root urinary calcium excretion with protein-corrected serum calcium was 1.78 (95% confidence interval, 1.21 to 2.34) mg/24 h per milligram per deciliter in women and 0.59 (95% confidence interval, -0.11 to 1.29) mg/24 h per milligram per deciliter in men. Men in the third 25(OH)D3 tertile had higher square root urinary calcium excretion than men in the first tertile (0.99; 95% confidence interval, 0.36 to 1.63 mg/24 h per nanogram per milliliter), and the corresponding association was 0.32 (95% confidence interval, -0.22 to 0.85) mg/24 h per nanogram per milliliter in women. These sex differences were more marked under conditions of high urinary sodium or urea excretions.
There was a positive association of serum calcium with urinary calcium excretion in women but not men. Vitamin 25(OH)D3 was associated with urinary calcium excretion in men but not women. These results suggest important sex differences in the hormonal and dietary control of urinary calcium excretion.
基于人群的尿钙排泄数据稀缺。在一项基于人群的研究中，探讨了血清钙和维生素D[25(OH)D2或D3]循环水平与男性和女性尿钙排泄之间的关联。
设计、地点、参与者与测量方法：在瑞士盐类研究调查中，采用多变量线性回归分析，以平方根转换后的24小时尿钙排泄量（毫克/24小时）作为因变量，重点研究特定月份的维生素D三分位数和血清钙与尿钙排泄的相关因素。
共研究了624名男性和669名女性，平均年龄分别为49.2岁和47.0岁（年龄范围=15 - 95岁）。男性的平均尿钙排泄量高于女性（183.05对144.60毫克/24小时；P<0.001）。在调整模型中，女性经蛋白质校正的血清钙每毫克/分升与平方根尿钙排泄量的关联（95%置信区间）为1.78（95%置信区间，1.21至2.34）毫克/24小时，男性为0.59（95%置信区间，-0.11至1.29）毫克/24小时。处于第三个25(OH)D3三分位数的男性的平方根尿钙排泄量高于处于第一个三分位数的男性（0.99；95%置信区间，0.36至1.63毫克/24小时/纳克/毫升），而女性的相应关联为0.32（95%置信区间，-0.22至0.85）毫克/24小时/纳克/毫升。在高尿钠或高尿素排泄情况下这些性别差异更为明显。
血清钙与女性而非男性的尿钙排泄呈正相关。维生素25(OH)D3与男性而非女性的尿钙排泄相关。这些结果表明在尿钙排泄的激素和饮食控制方面存在重要的性别差异。
