Yang Xianglin, Li Xuelian, Zhou Baosen
Department of Clinical Epidemiology, First Affiliated Hospital, China Medical University, Shenyang, China.
Department of Epidemiology, School of Public Health, China Medical University, Shenyang, China.
Front Physiol. 2018 Jun 12;9:737. doi: 10.3389/fphys.2018.00737. eCollection 2018.
MicroRNAs (miRNAs) are a class of endogenous, short and non-coding RNAs that may play important roles in the pathogenesis of tumor. The associations between microRNA-499 rs3746444 polymorphism and cancer risk in different systems remain inconclusive. This article is aimed to obtain more exact estimation of these relationships through a meta-analysis based on 52,456 individuals. We retrieved relevant and eligible studies from Pubmed and Embase database up to January 10, 2018. ORs and 95% CIs were used to estimate the associations between miR-499 polymorphism and cancer susceptibility in different systems. All analyses were performed using the Stata 11.0 software. A total of 65 case-control studies were retrieved using explicit inclusion and exclusion criteria. The study included 23,762 cases and 28,694 controls. Overall cancer analysis showed the association between miR-499 polymorphism and susceptibility to cancer was significant. MicroRNA-499 rs3746444 was found to be significantly associated with increased risk of cancer of the respiratory system (CC vs. TT: OR = 1.575, 95% CI = 1.268-1.955, CC vs. TC+TT: OR = 1.527, 95% CI = 1.232-1.892), digestive system (CC vs. TT: OR = 1.153, 95% CI = 1.027-1.295; TC vs. TT: OR = 1.109, 95% CI = 1.046-1.176; CC+TC vs. TT: OR = 1.112, 95% CI = 1.018-1.216; CC vs. TC+TT: OR = 1.137, 95% CI = 1.016-1.272; C vs. T: OR = 1.112, 95% CI = 1.025-1.206), urinary system (TC vs. TT: OR = 1.307, 95% CI = 1.130-1.512; CC+TC vs. TT: OR = 1.259, 95% CI = 1.097-1.446; C vs. T: OR = 1.132, 95% CI = 1.014-1.264), and gynecological system (C vs. T: OR = 1.169, 95% CI = 1.002-1.364). In the subgroup analysis by ethnicity, the result showed that significant association with an increased cancer risk was found in Asian. Subgroup analysis based on type of tumor was also performed, miR-499 rs3746444 is associated with susceptibility of cervical squamous cell carcinoma, lung cancer, prostate cancer, and hepatocellular carcinoma.
微小RNA（miRNA）是一类内源性、短链非编码RNA，可能在肿瘤发病机制中发挥重要作用。微小RNA-499 rs3746444多态性与不同系统癌症风险之间的关联尚无定论。本文旨在通过对52456名个体进行的荟萃分析，更准确地评估这些关系。我们从截至2018年1月10日的Pubmed和Embase数据库中检索了相关且符合条件的研究。采用比值比（OR）和95%置信区间（CI）来评估miR-499多态性与不同系统癌症易感性之间的关联。所有分析均使用Stata 11.0软件进行。通过明确的纳入和排除标准，共检索到65项病例对照研究。该研究纳入了23762例病例和28694例对照。总体癌症分析表明，miR-499多态性与癌症易感性之间存在显著关联。发现微小RNA-499 rs3746444与呼吸系统癌症风险增加显著相关（CC与TT比较：OR = 1.575，95% CI = 1.268 - 1.955；CC与TC + TT比较：OR = 1.527，95% CI = 1.232 - 1.892），消化系统（CC与TT比较：OR = 1.153，95% CI = 1.027 - 1.295；TC与TT比较：OR = 1.109，95% CI = 1.046 - 1.176；CC + TC与TT比较：OR = 1.112，95% CI = 1.018 - 1.216；CC与TC + TT比较：OR = 1.137，95% CI = 1.016 - 1.272；C与T比较：OR = 1.112，95% CI = 1.025 - 1.206），泌尿系统（TC与TT比较：OR = 1.307，95% CI = 1.130 - 1.512；CC + TC与TT比较：OR = 1.259，95% CI = 1.097 - 1.446；C与T比较：OR = 1.132，95% CI = 1.014 - 1.264），以及妇科系统（C与T比较：OR = 1.169，95% CI = 1.002 - 1.364）。在按种族进行的亚组分析中，结果显示亚洲人群中与癌症风险增加存在显著关联。还基于肿瘤类型进行了亚组分析，miR-499 rs3746444与宫颈鳞状细胞癌、肺癌、前列腺癌和肝细胞癌的易感性相关。
