Song Qing-Kun, Li Jing, Huang Rong, Fan Jin-Hu, Zheng Rong-Shou, Zhang Bao-Ning, Zhang Bin, Tang Zhong-Hua, Xie Xiao-Ming, Yang Hong-Jian, He Jian-Jun, Li Hui, Li Jia-Yuan, Qiao You-Lin, Chen Wan-Qing
Beijing Key Laboratory of Cancer Therapeutic Vaccine, Beijing Shijitan Hospital, Capital Medical University, Beijing, China E-mail :
Asian Pac J Cancer Prev. 2014;15(22):10021-5. doi: 10.7314/apjcp.2014.15.22.10021.
The study aimed to describe the age distribution of breast cancer diagnosis among Chinese females for comparison with the United States and the European Union, and provide evidence for the screening target population in China.
Median age was estimated from hospital databases from 7 tertiary hospitals in China. Population-based data in China, United States and European Union was extracted from the National Central Cancer Registry, SEER program and GLOBOCAN 2008, respectively. Age-standardized distribution of breast cancer at diagnosis in the 3 areas was estimated based on the World Standard Population 2000.
The median age of breast cancer at diagnosis was around 50 in China, nearly 10 years earlier than United States and European Union. The diagnosis age in China did not vary between subgroups of calendar year, region and pathological characteristics. With adjustment for population structure, median age of breast cancer at diagnosis was 5054 in China, but 5559 in United States and European Union.
The median diagnosis age of female breast cancer is much earlier in China than in the United States and the European Union pointing to racial differences in genetics and lifestyle. Screening programs should start at an earlier age for Chinese women and age disparities between Chinese and Western women warrant further studies.
本研究旨在描述中国女性乳腺癌诊断的年龄分布情况，以便与美国和欧盟进行比较，并为中国的筛查目标人群提供依据。
从中国7家三级医院的数据库中估算中位年龄。中国、美国和欧盟基于人群的数据分别从国家中央癌症登记处、监测、流行病学和最终结果（SEER）计划以及全球癌症观察站2008中提取。根据2000年世界标准人口估算这3个地区乳腺癌诊断时的年龄标准化分布。
中国乳腺癌诊断的中位年龄约为50岁，比美国和欧盟早近10年。中国的诊断年龄在历年、地区和病理特征亚组之间没有差异。调整人口结构后，中国乳腺癌诊断的中位年龄为50至54岁，而美国和欧盟为55至59岁。
中国女性乳腺癌的中位诊断年龄比美国和欧盟早得多，这表明在遗传和生活方式方面存在种族差异。中国女性的筛查计划应从更早的年龄开始，并且中国和西方女性之间的年龄差异值得进一步研究。
