Kruk Joanna
Department of Prevention and Occupational Therapy, Faculty of Physical Culture and Health Promotion, University of Szczecin, Poland E-mail :
Asian Pac J Cancer Prev. 2014;15(22):9579-86. doi: 10.7314/apjcp.2014.15.22.9579.
There is growing scientific evidence linking excess body weight to breast cancer risk. However, there is no common consensus on this relation due partly to methodologies used, populations studied and the cancer subtype. We report here a summary of the present state of knowledge on the role of overweight and obesity in pathogenesis of breast cancer and possible mechanisms through which excess body weight might influence the risk, focusing on the role of oxidative stress in breast cancer etiology. The findings demonstrate duality of excess body weight action in dependence on menopausal status: a statistically significant increased risk in postmenopausal overweight/ obese women and non-significant preventive effect among premenopausal women. Due to several gaps in the literature on this topic, additional studies are needed. Future research should address factors influencing the excess body weight - breast cancer relationship, such as race/ethnicity, tumor subtype, receptor status, the most appropriate measure of adiposity, reproductive characteristics, and lifestyle components.
越来越多的科学证据表明，超重与患乳腺癌的风险有关。然而，由于所使用的方法、研究的人群以及癌症亚型等因素，对于这种关系尚无普遍共识。我们在此报告关于超重和肥胖在乳腺癌发病机制中的作用以及超重可能影响风险的潜在机制的现有知识总结，重点关注氧化应激在乳腺癌病因学中的作用。研究结果表明，超重的作用因绝经状态而异：绝经后超重/肥胖女性患癌风险在统计学上显著增加，而绝经前女性则有不显著的预防作用。鉴于该主题的文献存在若干空白，需要进行更多研究。未来的研究应探讨影响超重与乳腺癌关系的因素，如种族/民族、肿瘤亚型、受体状态、最合适的肥胖衡量指标、生殖特征和生活方式因素。
