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药品不良反应监测:药物警戒的前景与迫在眉睫的挑战

Adverse drug reactions monitoring: prospects and impending challenges for pharmacovigilance.

作者信息

Sahu Ram Kumar, Yadav Rajni, Prasad Pushpa, Roy Amit, Chandrakar Shashikant

机构信息

Columbia Institute of Pharmacy, Tekari, Raipur, CG 493111 India.

出版信息

Springerplus. 2014 Nov 26;3:695. doi: 10.1186/2193-1801-3-695. eCollection 2014.

Abstract

Pharmacovigilance plays a consequential role in the surveillance of adverse drug reactions, which is provoked by the drugs used to cure diseases. Adverse drug reactions (ADRs) produce detrimental or undesirable effects to the body after administration of drugs. It has been reported that the number of patients dying because of contrary effects of drugs per year increased upto 2.6-fold. Moreover, rates of hospitalization of patients are increasing owing to adverse effects of drugs. Thus, it becomes challengeable for physician, health care providers, WHO and pharmaceutical industries to resolve the associated problem of ADRs. During the clinical trial of a novel drug, it is prominent to explore the dependability of drug. In this review, we documented the details required to identify the ADRs in patients along with reported banned drugs.

摘要

药物警戒在监测药物不良反应中起着至关重要的作用,这些不良反应是由用于治疗疾病的药物引发的。药物不良反应(ADR)在给药后会对身体产生有害或不良影响。据报道,每年因药物不良反应死亡的患者数量增加了2.6倍。此外,由于药物的不良反应,患者的住院率也在上升。因此,对于医生、医疗保健提供者、世界卫生组织和制药行业来说,解决药物不良反应的相关问题具有挑战性。在一种新药的临床试验期间,探索药物的可靠性非常重要。在本综述中,我们记录了识别患者药物不良反应所需的详细信息以及已报道的禁用药物。

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