Sirili Nathanael, Kilonzi Manase, Mwakawanga Dorkasi L, Mohamedi Juma A, Thobias Joseph Matobo, Clement Aurelia, Mwasomola Davance, Mushy Stella E
School of Public Health and Social Sciences, Muhimbili University of Health and Allied Sciences, P.O. Box 65015, Dar es Salaam, Tanzania.
School of Pharmacy, Muhimbili University of Health and Allied Sciences, P.O. Box 65013, Dar es Salaam, Tanzania.
Adv Pharmacol Pharm Sci. 2023 May 9;2023:7761649. doi: 10.1155/2023/7761649. eCollection 2023.
This study assessed the awareness, actions, and predictors of actions on adverse drug reaction reporting among patients attending a referral hospital in southern highland Tanzania.
A hospital-based cross-sectional study was conducted from January to August 2022 at Mbeya Zonal Referral Hospital (MZRH) in Mbeya, Tanzania. A total of 792 adult patients with chronic conditions attending outpatient clinics at MZRH were recruited consecutively. A semistructured questionnaire was used to collect demographic characteristics, ADR awareness, and actions when encountering ADR. Data were analyzed using the statistical package for social sciences (SPSS) version 23 and results are summarized using frequency and percentages. Binary logistic regression was used to assess the predictors associated with reporting ADR among patients. value ≤0.05 was considered statistically significant.
Out of 792, 397 (50.1%) were males and 383 (48.6%) had a primary education level. Only 171 (21.6%) participants previously experienced ADR, and 111 (14.1%) were aware that ADR is an unexpected harm that occurs after medication use. The majority 597 (70.3%) of the participants said will report ADR to healthcare providers, 706 (88.9%) prefer reporting ADR to healthcare providers, and 558 (69.1%) said patients are not aware of the importance of reporting ADR. Patients aged below 65 years of age, unemployed ((AOR (95% CI) = 0.4 (0.18-0.87), self-employed ((AOR (95% CI) = 0.5 (0.32-0.83)), and those who ever encountered ADR ((AOR (95% CI) = 0.1 (0.05-0.11)) were more likely to report the ADR to HCPs compared to the rest.
The majority of patients are not aware of what is ADR and the importance of ADR reporting. Most of the patients prefer to report ADR to healthcare providers. We recommend an awareness campaign to raise awareness of the patients on ADR and other methods of ADR reporting.
本研究评估了坦桑尼亚南部高地一家转诊医院患者对药物不良反应报告的知晓情况、行动及行动的预测因素。
2022年1月至8月在坦桑尼亚姆贝亚的姆贝亚地区转诊医院（MZRH）开展了一项基于医院的横断面研究。连续招募了792名在MZRH门诊就诊的患有慢性病的成年患者。使用半结构化问卷收集人口统计学特征、药物不良反应知晓情况以及遇到药物不良反应时的行动。使用社会科学统计软件包（SPSS）23版对数据进行分析，并使用频率和百分比汇总结果。采用二元逻辑回归评估患者中与报告药物不良反应相关的预测因素。P值≤0.05被认为具有统计学意义。
在792名患者中，397名（50.1%）为男性，383名（48.6%）的教育程度为小学。只有171名（21.6%）参与者曾经历过药物不良反应，111名（14.1%）知晓药物不良反应是用药后发生的意外伤害。大多数参与者597名（70.3%）表示会向医疗服务提供者报告药物不良反应，706名（88.9%）倾向于向医疗服务提供者报告药物不良反应，558名（69.1%）表示患者不了解报告药物不良反应的重要性。与其他患者相比，年龄在65岁以下、失业（优势比（95%置信区间）=0.4（0.18 - 0.87））、个体经营（优势比（95%置信区间）=0.5（0.32 - 0.83））以及曾遇到过药物不良反应（优势比（95%置信区间）=0.1（0.05 - 0.11））的患者更有可能向医疗服务提供者报告药物不良反应。
大多数患者不了解什么是药物不良反应以及报告药物不良反应的重要性。大多数患者倾向于向医疗服务提供者报告药物不良反应。我们建议开展提高认识活动，以提高患者对药物不良反应及其他药物不良反应报告方法的认识。
