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核蛋白与MCF13和Akv鼠白血病病毒长末端重复序列区域的差异DNA结合

Differential DNA binding of nuclear proteins to a long terminal repeat region of the MCF13 and Akv murine leukemia viruses.

作者信息

Yoshimura F K, Tupper J, Diem K

机构信息

Department of Biological Structure, University of Washington, Seattle 98195.

出版信息

J Virol. 1989 Nov;63(11):4945-8. doi: 10.1128/JVI.63.11.4945-4948.1989.

DOI:10.1128/JVI.63.11.4945-4948.1989
PMID:2552174
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC251142/
Abstract

Long terminal repeat (LTR) sequences of murine leukemia viruses (MLVs) have been demonstrated to be mainly responsible for the pathogenic differences in these retroviruses. A region of the LTR which is downstream of the enhancer elements has been shown to contribute both to enhancer activity as well as to disease specificity of MLVs. We have identified protein-DNA complexes generated by this region of a lymphomagenic MLV (MCF13) and one which is nonpathogenic (Akv). One protein-DNA complex we have observed for this region is unique to MCF13 DNA sequences. Detection of protein involved in this unique MCF13 complex in different cell lines revealed that it was ubiquitous.

摘要

小鼠白血病病毒（MLV）的长末端重复序列（LTR）已被证明是这些逆转录病毒致病性差异的主要原因。LTR中增强子元件下游的一个区域已被证明既有助于增强子活性，也有助于MLV的疾病特异性。我们已经鉴定出由致淋巴瘤性MLV（MCF13）的这一区域和一种非致病性MLV（Akv）产生的蛋白质-DNA复合物。我们在该区域观察到的一种蛋白质-DNA复合物是MCF13 DNA序列所特有的。在不同细胞系中检测参与这种独特的MCF13复合物的蛋白质，发现它普遍存在。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4677/251142/1672004d5339/jvirol00078-0485-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4677/251142/e626ba80a926/jvirol00078-0484-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4677/251142/aa5f6ceb946f/jvirol00078-0485-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4677/251142/b9880b60d1d3/jvirol00078-0485-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4677/251142/1672004d5339/jvirol00078-0485-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4677/251142/e626ba80a926/jvirol00078-0484-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4677/251142/aa5f6ceb946f/jvirol00078-0485-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4677/251142/b9880b60d1d3/jvirol00078-0485-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4677/251142/1672004d5339/jvirol00078-0485-c.jpg

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本文引用的文献

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Characterization of enhancer elements in the long terminal repeat of Moloney murine sarcoma virus.莫洛尼鼠肉瘤病毒长末端重复序列中增强子元件的特性分析。
J Virol. 1984 Jan;49(1):183-9. doi: 10.1128/JVI.49.1.183-189.1984.
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Determination of the leukaemogenicity of a murine retrovirus by sequences within the long terminal repeat.通过长末端重复序列内的序列测定鼠逆转录病毒的致白血病性。
Nature. 1984;308(5958):467-70. doi: 10.1038/308467a0.
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Role for the 3' end of the genome in determining disease specificity of Friend and Moloney murine leukemia viruses.
鉴定具有新型转录调控活性的鼠白血病病毒长末端重复序列区域。
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Pathogenic determinants in the U3 region of recombinant murine leukemia viruses isolated from CWD and HRS/J mice.从慢性消耗病（CWD）和HRS/J小鼠中分离出的重组鼠白血病病毒U3区域的致病决定因素。
J Virol. 1994 Aug;68(8):5174-83. doi: 10.1128/JVI.68.8.5174-5183.1994.
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Characterization of nuclear protein binding to a site in the long terminal repeat of a murine leukemia virus: comparison with the NFAT complex.核蛋白与鼠白血病病毒长末端重复序列中一个位点结合的特性：与NFAT复合物的比较。
J Virol. 1995 Feb;69(2):994-1000. doi: 10.1128/JVI.69.2.994-1000.1995.
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Function of a unique sequence motif in the long terminal repeat of feline leukemia virus isolated from an unusual set of naturally occurring tumors.从一组不寻常的自然发生肿瘤中分离出的猫白血病病毒长末端重复序列中独特序列基序的功能。
J Virol. 1995 Jun;69(6):3324-32. doi: 10.1128/JVI.69.6.3324-3332.1995.
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J Virol. 1992 Dec;66(12):7080-8. doi: 10.1128/JVI.66.12.7080-7088.1992.
基因组3'端在决定弗瑞德和莫洛尼鼠白血病病毒疾病特异性中的作用。
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Proc Natl Acad Sci U S A. 1983 Jul;80(14):4203-7. doi: 10.1073/pnas.80.14.4203.
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Nucleic Acids Res. 1981 Jul 10;9(13):3047-60. doi: 10.1093/nar/9.13.3047.
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Nature. 1984;312(5990):159-62. doi: 10.1038/312159a0.
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Promoter dependence of enhancer activity.增强子活性对启动子的依赖性。
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The tandem direct repeats within the long terminal repeat of murine leukemia viruses are the primary determinant of their leukemogenic potential.鼠白血病病毒长末端重复序列中的串联直接重复序列是其致白血病潜力的主要决定因素。
J Virol. 1984 Dec;52(3):945-52. doi: 10.1128/JVI.52.3.945-952.1984.
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Mapping the viral sequences conferring leukemogenicity and disease specificity in Moloney and amphotropic murine leukemia viruses.绘制莫洛尼氏和嗜双性鼠白血病病毒中赋予致白血病性和疾病特异性的病毒序列图谱。
J Virol. 1984 Nov;52(2):448-56. doi: 10.1128/JVI.52.2.448-456.1984.
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The envelope gene and long terminal repeat sequences contribute to the pathogenic phenotype of helper-independent Friend viruses.包膜基因和长末端重复序列促成了非辅助性弗氏病毒的致病表型。
J Virol. 1984 Sep;51(3):788-94. doi: 10.1128/JVI.51.3.788-794.1984.