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1
Promoter dependence of enhancer activity.增强子活性对启动子的依赖性。
Mol Cell Biol. 1984 Aug;4(8):1664-8. doi: 10.1128/mcb.4.8.1664-1668.1984.
2
Differential activation of the mouse beta-globin promoter by enhancers.增强子对小鼠β-珠蛋白启动子的差异激活作用。
Mol Cell Biol. 1983 Jul;3(7):1246-54. doi: 10.1128/mcb.3.7.1246-1254.1983.
3
Photoaffinity labeling with GTP of viral p21 ras protein expressed in Escherichia coli.用GTP对在大肠杆菌中表达的病毒p21 ras蛋白进行光亲和标记。
J Virol. 1984 May;50(2):343-51. doi: 10.1128/JVI.50.2.343-351.1984.
4
Enhanced transformation by a simian virus 40 recombinant virus containing a Harvey murine sarcoma virus long terminal repeat.含有哈维鼠肉瘤病毒长末端重复序列的猿猴病毒40重组病毒增强的转化作用。
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5
Adenovirus-2 E1A products repress enhancer-induced stimulation of transcription.腺病毒2型E1A产物可抑制增强子诱导的转录激活。
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6
Powerful and versatile enhancer-promoter unit for mammalian expression vectors.用于哺乳动物表达载体的强大且通用的增强子-启动子单元。
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7
Mutational analyses of the Moloney murine sarcoma virus enhancer.莫洛尼鼠肉瘤病毒增强子的突变分析
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Genes Dev. 1987 Apr;1(2):133-46. doi: 10.1101/gad.1.2.133.

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8
Nucleotides in the polyomavirus enhancer that control viral transcription and DNA replication.多瘤病毒增强子中控制病毒转录和DNA复制的核苷酸。
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9
Construction and characterization of hybrid polyomavirus genomes.杂交多瘤病毒基因组的构建与特性分析
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Optimizing gene expression in BPV-transformed cells: effects of cell type on enhancer/promoter interaction.优化牛乳头瘤病毒（BPV）转化细胞中的基因表达：细胞类型对增强子/启动子相互作用的影响。
Nucleic Acids Res. 1987 Sep 11;15(17):7137-53. doi: 10.1093/nar/15.17.7137.

本文引用的文献

1
Characterization of enhancer elements in the long terminal repeat of Moloney murine sarcoma virus.莫洛尼鼠肉瘤病毒长末端重复序列中增强子元件的特性分析。
J Virol. 1984 Jan;49(1):183-9. doi: 10.1128/JVI.49.1.183-189.1984.
2
Correlation of gene expression and transformation frequency with the presence of an enhancing sequence in the transforming DNA.基因表达和转化频率与转化DNA中增强序列存在情况的相关性。
Mol Cell Biol. 1984 Feb;4(2):368-70. doi: 10.1128/mcb.4.2.368-370.1984.
3
A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene.一种组织特异性转录增强子元件位于重排的免疫球蛋白重链基因的主要内含子中。
Cell. 1983 Jul;33(3):717-28. doi: 10.1016/0092-8674(83)90014-4.
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Magic enhancers?神奇的增强剂？
DNA. 1984;3(1):1-5. doi: 10.1089/dna.1.1984.3.1.
5
Transcriptional activation of cloned human beta-globin genes by viral immediate-early gene products.病毒立即早期基因产物对克隆的人β-珠蛋白基因的转录激活作用。
Cell. 1983 Nov;35(1):137-48. doi: 10.1016/0092-8674(83)90216-7.
6
Differential activation of the mouse beta-globin promoter by enhancers.增强子对小鼠β-珠蛋白启动子的差异激活作用。
Mol Cell Biol. 1983 Jul;3(7):1246-54. doi: 10.1128/mcb.3.7.1246-1254.1983.
7
Simian virus 40 early- and late-region promoter functions are enhanced by the 72-base-pair repeat inserted at distant locations and inverted orientations.猿猴病毒40早期和晚期区域启动子功能可通过插入到远处位置且方向相反的72碱基对重复序列得到增强。
Mol Cell Biol. 1983 Jun;3(6):991-9. doi: 10.1128/mcb.3.6.991-999.1983.
8
Bovine papilloma virus contains an activator of gene expression at the distal end of the early transcription unit.牛乳头瘤病毒在早期转录单元的远端含有一个基因表达激活剂。
Mol Cell Biol. 1983 Jun;3(6):1108-22. doi: 10.1128/mcb.3.6.1108-1122.1983.
9
Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA.逆转录病毒和SV40序列在DNA显微注射后增强生化转化的位置及功能。
Cell. 1983 Jul;33(3):705-16. doi: 10.1016/0092-8674(83)90013-2.
10
Transcriptional enhancer elements in the mouse immunoglobulin heavy chain locus.小鼠免疫球蛋白重链基因座中的转录增强子元件。
Science. 1983 Aug 12;221(4611):663-5. doi: 10.1126/science.6306772.

增强子活性对启动子的依赖性。

Promoter dependence of enhancer activity.

作者信息

Berg P E, Popovic Z, Anderson W F

出版信息

Mol Cell Biol. 1984 Aug;4(8):1664-8. doi: 10.1128/mcb.4.8.1664-1668.1984.

DOI:10.1128/mcb.4.8.1664-1668.1984
PMID:6092930
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC368966/
Abstract

The interaction of enhancers with different promoters was studied by measuring the influence of two enhancers (from simian virus 40 and from Harvey sarcoma virus) on the activity of expression vectors that are identical except for their promoter region. The promoters examined were from the simian virus 40 early region, with or without its own 72-base-pair repeat, and the mouse beta major-globin gene. It is clear that the promoter acted upon strongly influences the level of activity of an enhancer.

摘要

通过测量两种增强子（来自猿猴病毒40和哈维肉瘤病毒）对除启动子区域外完全相同的表达载体活性的影响，研究了增强子与不同启动子之间的相互作用。所检测的启动子分别来自猿猴病毒40早期区域，有或没有其自身的72碱基对重复序列，以及小鼠β-珠蛋白基因。显然，受作用的启动子对增强子的活性水平有很大影响。