增强子活性对启动子的依赖性。
Promoter dependence of enhancer activity.
作者信息
Berg P E, Popovic Z, Anderson W F
出版信息
Mol Cell Biol. 1984 Aug;4(8):1664-8. doi: 10.1128/mcb.4.8.1664-1668.1984.
Abstract
The interaction of enhancers with different promoters was studied by measuring the influence of two enhancers (from simian virus 40 and from Harvey sarcoma virus) on the activity of expression vectors that are identical except for their promoter region. The promoters examined were from the simian virus 40 early region, with or without its own 72-base-pair repeat, and the mouse beta major-globin gene. It is clear that the promoter acted upon strongly influences the level of activity of an enhancer.
摘要
通过测量两种增强子（来自猿猴病毒40和哈维肉瘤病毒）对除启动子区域外完全相同的表达载体活性的影响，研究了增强子与不同启动子之间的相互作用。所检测的启动子分别来自猿猴病毒40早期区域，有或没有其自身的72碱基对重复序列，以及小鼠β-珠蛋白基因。显然，受作用的启动子对增强子的活性水平有很大影响。
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