Wang Xiaoyan, Zhang Hao, Zhang Xiaonian, Sun Xinting, Zhang Tong
Rehabilitation Medicine College of Capital Medical University, Chinese Rehabilitation Research Center, The Beijing Boai Hospital, Beijing City, China.
Neuroreport. 2015 Jan 21;26(2):50-6. doi: 10.1097/WNR.0000000000000288.
To observe changes in mismatch negativity (MMN) and P300 in a patient transitioning from a vegetative state (VS) to a minimally conscious state (MCS). One patient with intracerebral hemorrhage and an 8-month disease course was evaluated as being in the VS using the Coma Recovery Scale-Revised. Two weeks after the patient was admitted to the hospital, another evaluation was performed, and the patient was determined to be in an MCS. Using the Oddball paradigm, pure tone and name stimuli were presented to the patient to study event-related potentials (ERPs). A 15-week clinical follow-up was carried out, and four ERP examinations were performed at 2 days and 2, 6, and 15 weeks after admission. One healthy individual was assessed as a control participant. MMN and P300 were elicited in all four ERP examinations. MMN and P300 may occur earlier than believed in patients in persistent VS and MCS; their predictive values for prognosis need to be further confirmed by follow-up studies on a large clinical sample.
观察一名从植物状态（VS）转变为微意识状态（MCS）患者的失匹配负波（MMN）和P300的变化。一名脑出血患者，病程8个月，使用修订版昏迷恢复量表评估为处于VS状态。患者入院两周后进行了另一次评估，确定其处于MCS状态。采用Oddball范式，向患者呈现纯音和名字刺激以研究事件相关电位（ERP）。进行了为期15周的临床随访，并在入院后2天以及2、6和15周进行了四次ERP检查。评估一名健康个体作为对照参与者。在所有四次ERP检查中均引出了MMN和P300。MMN和P300在持续性VS和MCS患者中可能比预期更早出现；其对预后的预测价值需要通过对大量临床样本的随访研究进一步证实。
