Rehabilitation Medicine College of Capital Medical University, Chinese Rehabilitation Research Center, Beijing Boai Hospital, Beijing, China.
Eur Rev Med Pharmacol Sci. 2017 Nov;21(21):4896-4906.
To evaluate changes in mismatch negativity (MMN) and P300 response in vegetative state (VS) and minimally conscious state (MCS) patients before and after treatment, and their value for prediction of prognosis.
Event-related potentials (ERPs), performed on 11 patients classified as VS (n = 6) or MCS (n = 5), and five healthy participants (i.e., control group). We performed a six months telephone follow-up to monitor changes in consciousness recovery.
Comparison of the three groups showed significantly higher MMN latency elicited by salient stimuli and P300 elicited by the subject's own name for the VS group, as well as significant difference in amplitudes of MMN elicited by frequent stimuli and P300 elicited by other first names for this group. The source of MMN and P300 responses was the frontal lobe for the control group, and temporal lobe for the VS and MCS groups.
The sudden increase in MMN amplitude and latency shortening may indicate an improvement in the state of consciousness. Neurophysiological evaluations suggest that patients with vegetative state (VS) and minimally conscious state (MCS) may preserve patterns of higher-order cerebral processing similar to those observed in conscious patients.
评估植物状态（VS）和最小意识状态（MCS）患者治疗前后失匹配负波（MMN）和 P300 反应的变化及其对预后预测的价值。
对 11 名被分类为 VS（n=6）或 MCS（n=5）的患者和 5 名健康参与者（即对照组）进行事件相关电位（ERPs）。我们进行了为期 6 个月的电话随访，以监测意识恢复的变化。
三组比较显示，VS 组对显著刺激诱发的 MMN 潜伏期和对自身姓名诱发的 P300 潜伏期明显延长，且对高频刺激诱发的 MMN 振幅和对其他姓名诱发的 P300 振幅也有显著差异。对照组 MMN 和 P300 反应的源是额叶，VS 和 MCS 组是颞叶。
MMN 振幅的突然增加和潜伏期的缩短可能表明意识状态的改善。神经生理评估表明，处于植物状态（VS）和最小意识状态（MCS）的患者可能保留了类似于清醒患者的高级大脑处理模式。
