Tizzani A, Casetta G, Piana P, Vercelli D
Institute of Nephro-Urology, University of Torino, Italy.
J Urol. 1989 Oct;142(4):1018-20. doi: 10.1016/s0022-5347(17)38973-5.
The binding properties of raw vegetable fiber towards bivalent cations suggested the prescription of brain as a dietary supplement to limit intestinal calcium absorption in hypercalciuric patients. A group of 18 patients with a specific diagnosis of absorptive hypercalciuria received a dietary supplement of 14 gm. wheat bran at the 2 principal meals for 90 days. A complete assessment of mineral metabolism was performed after 45 and 90 days. Mean basal calciuria was 357 mg. per 24 hours and a significant decrease was noted after 45 days (245 mg. per 24 hours) and 90 days (240 mg. per 24 hours), with a p value of less than 0.01. Urinary oxalate did not vary significantly (0.34 to 0.38 to 0.31 mMol. per 24 hours) and neither did phosphate levels (1,020 to 900 to 893 mg. per 24 hours). A slight and pathologically insignificant decrease was noted in serum iron and urinary magnesium; this fact could be considered a side effect owing to the nonselective binding properties of fiber. Therefore, the positive results achieved confirm the effective action of wheat bran in the treatment of correctly diagnosed absorptive hypercalciuria.
天然植物纤维对二价阳离子的结合特性表明，可将麦麸作为膳食补充剂开给高钙尿症患者，以限制肠道对钙的吸收。一组18例确诊为吸收性高钙尿症的患者在两顿主餐中服用14克麦麸作为膳食补充剂，持续90天。在45天和90天后对矿物质代谢进行了全面评估。平均基础尿钙为每24小时357毫克，45天后（每24小时245毫克）和90天后（每24小时240毫克）显著下降，p值小于0.01。尿草酸盐无显著变化（每24小时0.34至0.38至0.31毫摩尔），磷酸盐水平也无变化（每24小时1,020至900至893毫克）。血清铁和尿镁略有下降，但在病理学上无显著意义；由于纤维的非选择性结合特性，这一事实可被视为一种副作用。因此，所取得的阳性结果证实了麦麸在治疗确诊的吸收性高钙尿症中的有效作用。
