Ohkawa T, Ebisuno S, Kitagawa M, Morimoto S, Miyazaki Y, Yasukawa S
J Urol. 1984 Dec;132(6):1140-5. doi: 10.1016/s0022-5347(17)50065-8.
The purpose of this study is to confirm the hypocalciuric effect of rice bran experimentally and clinically. Urinary calcium excretion and its absorption in the intestine were reduced significantly by rice bran or phytin in rats fed high calcium diets, while there were no significant decreases with a low calcium diet. For the clinical study 70 patients with idiopathic hypercalciuria were treated with rice bran (10 gm. twice daily) for 1 month to 3 years. In almost all patients rice bran caused a significant decrease in urinary calcium excretion, which was maintained during treatment. Evidence of stones has decreased clearly among patients treated with rice bran for 1 to 3 years, although this might be a halfway judgment of the long-term treatment. We suggest that phytin should be the most effective substance to reduce the intestinal absorption of calcium and that rice bran treatment should be effective for prevention of recurrent urinary stone disease.
本研究的目的是通过实验和临床来证实米糠的降钙尿作用。在喂食高钙饮食的大鼠中，米糠或肌醇六磷酸可显著降低尿钙排泄及其在肠道中的吸收，而低钙饮食则无显著降低。在临床研究中，70例特发性高钙尿症患者接受米糠治疗（每日两次，每次10克），治疗时间为1个月至3年。几乎所有患者的米糠都使尿钙排泄显著降低，且在治疗期间持续存在。在接受米糠治疗1至3年的患者中，结石证据明显减少，尽管这可能是长期治疗的中期判断。我们认为肌醇六磷酸应该是减少肠道钙吸收最有效的物质，米糠治疗对预防复发性尿路结石病应该是有效的。
