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一种用于直接监测病毒感染和中和抗体筛选的重组禽白血病病毒J亚群。

A recombinant avian leukosis virus subgroup j for directly monitoring viral infection and the selection of neutralizing antibodies.

作者信息

Wang Qi, Li Xiaofei, Ji Xiaolin, Wang Jingfei, Shen Nan, Gao Yulong, Qi Xiaole, Wang Yongqiang, Gao Honglei, Zhang Shide, Wang Xiaomei

机构信息

Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150001, China.

Centre for Animal Infectious Disease Diagnosis and Technical Services and State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150001, China.

出版信息

PLoS One. 2014 Dec 18;9(12):e115422. doi: 10.1371/journal.pone.0115422. eCollection 2014.

DOI:10.1371/journal.pone.0115422
PMID:25522008
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4270768/
Abstract

Avian leukosis virus subgroup J (ALV-J) has induced serious clinical outbreaks and has become a serious infectious disease of chickens in China. We describe here the creation of a recombinant ALV-J tagged with the enhanced green fluorescent protein (named rHPRS-103EGFP). We successfully utilize the rHPRS-103EGFP to visualize viral infection and for development of a simplified serum-neutralization test.

摘要

禽白血病病毒J亚群（ALV-J）已引发严重的临床疫情，在中国已成为鸡的一种严重传染病。我们在此描述了一种标记有增强型绿色荧光蛋白的重组ALV-J（命名为rHPRS-103EGFP）的构建。我们成功利用rHPRS-103EGFP来观察病毒感染情况，并用于开发一种简化的血清中和试验。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e1/4270768/b224645c4a51/pone.0115422.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e1/4270768/f1e8dc0be409/pone.0115422.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e1/4270768/1875818507a0/pone.0115422.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e1/4270768/434e1650e4f0/pone.0115422.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e1/4270768/890550be4776/pone.0115422.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e1/4270768/b224645c4a51/pone.0115422.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e1/4270768/f1e8dc0be409/pone.0115422.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e1/4270768/1875818507a0/pone.0115422.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e1/4270768/434e1650e4f0/pone.0115422.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e1/4270768/890550be4776/pone.0115422.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e1/4270768/b224645c4a51/pone.0115422.g005.jpg

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本文引用的文献

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PLoS One. 2014 Jan 20;9(1):e84797. doi: 10.1371/journal.pone.0084797. eCollection 2014.
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Simplified serum neutralization test based on enhanced green fluorescent protein-tagged classical swine fever virus.基于增强型绿色荧光蛋白标记的经典猪瘟病毒的简化血清中和试验。
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Viruses. 2016 May 6;8(5):127. doi: 10.3390/v8050127.
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Correction: a recombinant avian leukosis virus subgroup J for directly monitoring viral infection and the selection of neutralizing antibodies.校正：一种用于直接监测病毒感染和中和抗体筛选的重组禽白血病病毒J亚群。
PLoS One. 2015 Apr 2;10(4):e0121770. doi: 10.1371/journal.pone.0121770. eCollection 2015.
Nonconserved tryptophan 38 of the cell surface receptor for subgroup J avian leukosis virus discriminates sensitive from resistant avian species.
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A 205-nucleotide deletion in the 3' untranslated region of avian leukosis virus subgroup J, currently emergent in China, contributes to its pathogenicity.在中国目前新兴的禽白血病病毒 J 亚群的 3'非翻译区存在 205 个核苷酸缺失，这有助于其致病性。
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