Feng Min, Zhang Xiquan
Department of Animal Genetics, Breeding and Reproduction, College of Animal Science, South China Agricultural University, Guangzhou, China; Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding and Key Lab of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou, China.
Front Immunol. 2016 Dec 21;7:624. doi: 10.3389/fimmu.2016.00624. eCollection 2016.
Avian leukosis virus (ALV) is an avian oncogenic retrovirus causing enormous economic losses in the global poultry industry. Although ALV-related research has lasted for more than a century, there are no vaccines to protect chickens from ALV infection. The interaction between chickens and ALV remains not fully understood especially with regard to the host immunity. The current review provides an overview of our current knowledge of innate and adaptive immunity induced by ALV infection. More importantly, we have pointed out the unknown area involved in ALV-related studies, which is worthy of our serious exploring in future.
禽白血病病毒（ALV）是一种禽类致癌逆转录病毒，在全球家禽业中造成巨大经济损失。尽管与ALV相关的研究已经持续了一个多世纪，但尚无疫苗可保护鸡免受ALV感染。鸡与ALV之间的相互作用仍未完全了解，尤其是在宿主免疫方面。本综述概述了我们目前对ALV感染诱导的固有免疫和适应性免疫的认识。更重要的是，我们指出了ALV相关研究中涉及的未知领域，值得我们在未来认真探索。
